Results 101 to 110 of about 12,263,286 (349)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Behavior Of Superconducting Fault Current Limiter Under Fault Condition
, 2017 Now a days due to increase in electricity demand for the purpose of industrialization, agriculture, domestic and educational etc there exists more chances of fault occurance. The Faults occurs due to insulation damaging, breaking of conductor, short circuit, lightning etc.
KARUNA L. BARI, S. M. SHEMBEKAR
openaire +3 more sources
Superconducting Fault Current Limiters for HVDC Systems
Energy Procedia, 2015 AbstractHigh-voltage direct current (HVDC) transmission systems using Voltage-Source Converters (VSC) are widely recognized as offering significant potential for long distance high power delivery, particularly for offshore wind farm connections. One of the barriers for the development of multi-terminal HVDC systems is the lack of technologies which ...
Pei, Xiaoze +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Research of protection for AC transmission lines based on characteristic of grid-side inverter
The Journal of Engineering, 2019 With the advantage of saving resources and high utilisation, DC transmission becomes the vital part of the sustainable development. However, due to the control strategies of grid-side inverter, the fault characteristics of the grid will change ...
Ning Huang, Chunju Fan, Shan Jiang
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Optimal power flow considering fault current level constraints and fault current limiters
International Journal of Electrical Power & Energy Systems, 2014 Abstract The aim of this paper is to present a novel method to dispatch the active generation power properly in the power system while incorporating fault current levels as constraints for the optimization problem. Due to the limited capacity of protective devices such as circuit breakers, allocating active power without considering fault current ...
Amirhossein Khazali, Mohsen Kalantar
openaire +1 more source