Results 91 to 100 of about 2,598,939 (297)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Research on Convolutional Neural Network Model for Sonar IMAGE Segmentation

MATEC Web of Conferences, 2018
The speckle noise of sonar images affects the human interpretation and automatic recognition of images seriously. It is important and difficult to realize the precision segmentation of sonar image with speckle noise in the field of image processing. Full
Jiao Shengxi, Zhao Chunyu, Xin Ye
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Dispersion characteristics of shear horizontal waves in piezoelectric nanoplates: a nonlocal strain gradient theory incorporating surface effects

Archives of Mechanics
This paper investigates the propagation of shear horizontal (SH) waves in piezoelectric nanoplates by coupling the Gurtin-Murdoch surface model with the nonlocal strain gradient theory.
X.H. Chen, X.M. Zhang, H.M. Zhou
doaj   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Fault Diagnosis of Wind Turbine Generators Based on Stacking Integration Algorithm and Adaptive Threshold

, 2023
Fault alarm time lag is one of the difficulties in fault diagnosis of wind turbine generators (WTGs), and the existing methods are insufficient to achieve accurate and rapid fault diagnosis of WTGs, and the operation and maintenance costs of WTGs are too
Huayu Zou, Yushi Yang, Zhanjun Tang, Yajia Zhang, Jianfeng He, Yuting Zhu, Xiaobing Shi   +6 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Wind Speed Interval Prediction Based on Bayesian Optimized Spatio-Temporal Integration and Compression Deep Residual Network

Sensors
To address the challenge of high wind speed variability in wind farm planning, a small-sample-based spatio-temporal fusion and compression deep residual point prediction model, STiCDRS (Spatio-Temporal integration and Compression Deep Residual), is ...
Yun Wu, Yongzhen Gong, Xiaoguo Chen, Xingang Wang, Xiaoyong Li   +4 more
doaj   +1 more source

Fault Diagnosis of Rotating Machinery Based on Wavelet Domain Denoising and Metric Distance

IEEE Access, 2019
In the monitoring process of petrochemical equipment rotating machinery, the collected large data easily lead to valuable data loss in the pre-processing process and affecting the accuracy of the fault diagnosis.
Naiquan Su, Xiao Li, Qianghua Zhang
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source