Results 81 to 90 of about 2,598,939 (297)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Fault Diagnosis of Rolling Bearing Based on a Priority Elimination Method

open access: yes, 2023
Aiming at the fault diagnosis accuracy of rolling bearings is not high enough, and unknown faults cannot be correctly identified. A priority elimination (PE) method is proposed in this paper.
Weichen Li   +4 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

DIAGNOSIS WITH A FUNCTION-FAULT MODEL

open access: yesApplied Artificial Intelligence, 1989
This paper introduces a domain model for use in diagnostic problem solving. It emphasizes functional decomposition, rather than behavior, cause-effect, or spatial structure, and represents explicitly the faults of a system together with its possible explanations.
openaire   +3 more sources

Exploring Research on the Construction and Application of Knowledge Graphs for Aircraft Fault Diagnosis

open access: yes, 2023
Fault diagnosis is crucial for repairing aircraft and ensuring their proper functioning. However, with the higher complexity of aircraft, some traditional diagnosis methods that rely on experience are becoming less effective.
Guo Chi   +5 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

An Online Classification Method for Fault Diagnosis of Railway Turnouts

open access: yes, 2020
Railway turnout system is a key infrastructure to railway safety and efficiency. However, it is prone to failure in the field. Therefore, many railway departments have adopted a monitoring system to monitor the operation status of turnouts.
Dongxiu Ou, Hu Liu, Lei Zhang, Yuqing Ji
core   +1 more source

An Imbalanced Fault Diagnosis Method Based on TFFO and CNN for Rotating Machinery

open access: yes, 2022
Deep learning-based fault diagnosis usually requires a rich supply of data, but fault samples are scarce in practice, posing a considerable challenge for existing diagnosis approaches to achieve highly accurate fault detection in real applications.
Muxu Luo   +11 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

Security and Privacy in Fog Computing: Challenges

open access: yesIEEE Access, 2017
Fog computing paradigm extends the storage, networking, and computing facilities of the cloud computing toward the edge of the networks while offloading the cloud data centers and reducing service latency to the end users. However, the characteristics of
Mithun Mukherjee   +6 more
doaj   +1 more source

Home - About - Disclaimer - Privacy