Results 91 to 100 of about 249,018 (300)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A Fault Estimation Method Based on UIO Robust Residual Generators

MATEC Web of Conferences, 2016
This paper proposed a fault estimation method based on robust residual generators for a linear system. A system with additive actuator or component faults was considered in the case where the number of the independent faults was larger than that of the ...
Liu Yongjin, Feng Gang, Zhang Lin, Wang Wenfeng, Jia Zhonghui, Zhang Bo   +5 more
doaj   +1 more source

Fault detection using parameter estimation

Quality and Reliability Engineering International, 1989
AbstractThis paper presents a brief summary of fault‐detection methods using parameter estimation techniques. An overview of the fault‐detection system design methodology is first presented, followed by the principles of parameter‐estimation fault‐detection techniques.
Πουλιεζος Αναστασιος(http://users.isc.tuc.gr/~apouliezos), Pouliezos Anastasios(http://users.isc.tuc.gr/~apouliezos), Σταυρακακης Γεωργιος(http://users.isc.tuc.gr/~gstavrakakis), Stavrakakis Georgios(http://users.isc.tuc.gr/~gstavrakakis), C. Lefas()   +4 more
openaire   +2 more sources

Distributed fault estimation for linear systems with actuator faults

International Journal of Robust and Nonlinear Control, 2020
SummaryThis article investigates the problem of designing a distributed fault estimation observer (DFEO) for a given linear time invariant observed system with disturbances. The DFEO consists of a network of local fault estimation observers. The local observers at the network nodes are physically distributed and hence each of them has access to only ...
Weixin Han, Harry L. Trentelman, Zhenhua Wang, Yi Shen   +3 more
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Fault Type Estimation in Power Systems

Iranian Journal of Electrical and Electronic Engineering, 2009
This paper presents a novel approach for fault type estimation in power systems. The Fault type estimation is the first step to estimate instantaneous voltage, voltage sag magnitude and duration in a three-phase system at fault duration.
J. Beiza, S. H. Hosseinian, B. Vahidi
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Performance Estimation and Fault Diagnosis Based on Levenberg–Marquardt Algorithm for a Turbofan Engine

Energies, 2018
Establishing the schemes of accurate and computationally efficient performance estimation and fault diagnosis for turbofan engines has become a new research focus and challenges.
Junjie Lu, Feng Lu, Jinquan Huang
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source