Results 81 to 90 of about 1,968,653 (288)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Distributed fault estimation for linear systems with actuator faults

International Journal of Robust and Nonlinear Control, 2020
SummaryThis article investigates the problem of designing a distributed fault estimation observer (DFEO) for a given linear time invariant observed system with disturbances. The DFEO consists of a network of local fault estimation observers. The local observers at the network nodes are physically distributed and hence each of them has access to only ...
Weixin Han, Harry L. Trentelman, Zhenhua Wang, Yi Shen   +3 more
openaire   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Paleoearthquakes of the Düzce fault (North Anatolian Fault Zone): Insights for large surface faulting earthquake recurrence [PDF]

, 2008
Copyright 2008 by the American Geophysical Union.The 12 November 1999 Mw 7.1 earthquake ruptured the Düzce segment of the North Anatolian Fault Zone and produced a ∼40-km-long surface rupture.
D. Pantosti, Palyvos, N, S. Pucci, C. Zabci, D'Addezio, G, N. Palyvos, Zabci, C, De Martini, PM, Zabci, C., Pucci, S, G. D'Addezio, Pucci, S., D'Addezio, G., Pantosti, D., P. E. F. Collins, Palyvos, N., P. M. De Martini, De Martini, P. M., Pantosti, D, Collins, PEF, Collins, P. E. F.   +20 more
core   +1 more source

Fault Type Estimation in Power Systems

Iranian Journal of Electrical and Electronic Engineering, 2009
This paper presents a novel approach for fault type estimation in power systems. The Fault type estimation is the first step to estimate instantaneous voltage, voltage sag magnitude and duration in a three-phase system at fault duration.
J. Beiza, S. H. Hosseinian, B. Vahidi
doaj  

Integrated Fault Estimation and Fault‐Tolerant Control for Dynamic Positioning of Ships

Mathematical Problems in Engineering, 2019
An integrated fault estimation and fault‐tolerant control scheme is developed in this paper for dynamic positioning of ships in the presence of an actuator fault. First, an auxiliary derivative output of dynamic positioning ships is constructed in order to satisfy the so‐called observer matching condition, and a high‐gain observer is designed to ...
Xiaogong Lin, Heng Li, Anzuo Jiang, Juan Li   +3 more
openaire   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source