Results 101 to 110 of about 28,700 (312)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Robust fault estimation for wind turbine energy via hybrid systems [PDF]
, 2017 The rapid development of modern wind turbine technology has led to increasing demand for improving system reliability and practical concern for robust fault monitoring scheme.
Edward Bentley +5 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Numerically reliable methods for optimal design of fault detection filters [PDF]
, 2005 The design problem of fault detection and isolation filters is formulated as a model matching problem and solved using an H2-or H1-norm optimization approach.
Varga, Andreas
core
Application of a Combined Active Control and Fault Detection Scheme to an Active Composite Flexible Structure. [PDF]
, 2006 In this paper, the problem of increasing reliability of active control procedure is considered. Indeed, a design method of rejection perturbation in presence of potentially faults, on a flexible structure with integrated piezo-ceramics, is presented. The
VERGÉ, Michel +3 more
core +1 more source
Energies, 2018 Establishing the schemes of accurate and computationally efficient performance estimation and fault diagnosis for turbofan engines has become a new research focus and challenges.
Junjie Lu, Feng Lu, Jinquan Huang
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
The fault detection and severity diagnosis of rolling element bearings using modulation signal bispectrum [PDF]
The rolling element bearing is a key part in many mechanical equipment. The accurate and timely diagnosis of its faults is critcal for predictive maintenance. Vibration signals from a defective bearing with a localized fault contain a series of impulsive
Gu, Fengshou +3 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A Desk-top tutorial Demonstration of Model-based Fault Detection and Diagnosis [PDF]
, 2007 In this paper, a demonstration on the model-based approach for fault detection has been presented. The aim of this demo is to provide students a desk-top tool to start learning model-based approach.
Gu, Fengshou +3 more
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