Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Fracture characteristics from two reactivated basement fault zones: examples from Norway and Shetland [PDF]
, 2001 Detailed analyses of fracture attributes developed in basement rocks associated with two, crustal-scale faults, have enabled the characteristics and evolution of the fracture system geometry to be documented quantitatively.
Sleight, Janine Michelle
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A new method for fault identification of T-connection transmission line based on multi-scale traveling wave reactive power and random forest. [PDF]
PLoS One, 2023 Zhong Y, Yang J, Wang S, Deng S, Hu L.
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A Vibration Fault Identification Framework for Shafting Systems of Hydropower Units: Nonlinear Modeling, Signal Processing, and Holographic Identification. [PDF]
Sensors (Basel), 2022 Shi Y, Zhou J, Huang J, Xu Y, Liu B.
europepmc +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Gearbox Fault Identification Model Using an Adaptive Noise Canceling Technique, Heterogeneous Feature Extraction, and Distance Ratio Principal Component Analysis. [PDF]
Sensors (Basel), 2022 Nguyen CD, Kim CH, Kim JM.
europepmc +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Diagnosis Methodology Based on Deep Feature Learning for Fault Identification in Metallic, Hybrid and Ceramic Bearings. [PDF]
Sensors (Basel), 2021 Saucedo-Dorantes JJ +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source