Results 121 to 130 of about 3,091,102 (249)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

A transmission line fault identification method based on Deep Forest and SMOTE

open access: yesZhejiang dianli
Power transmission line faults exhibit multi-causal origins and imbalanced occurrence frequencies across fault types, resulting in significant class imbalance in transient waveform data.
JIANG Kaihua   +6 more
doaj   +1 more source

Flow chart of the fault branch identification algorithm.

open access: yes, 2019
Flow chart of the fault branch identification algorithm.
Leilei Chen (214607)   +3 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Diagnosis Methodology Based on Deep Feature Learning for Fault Identification in Metallic, Hybrid and Ceramic Bearings. [PDF]

open access: yesSensors (Basel), 2021
Saucedo-Dorantes JJ   +3 more
europepmc   +1 more source

A framework and methods for on-board network level fault diagnostics in automobiles [PDF]

open access: yes
A significant number of electronic control units (ECUs) are nowadays networked in automotive vehicles to help achieve advanced vehicle control and eliminate bulky electrical wiring.
Suwatthikul, Jittiwut
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

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