Results 51 to 60 of about 111,641 (296)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Frictional Instabilities and Carbonation of Basalts Triggered by Injection of Pressurized H2O- and CO2- Rich Fluids [PDF]

open access: yes, 2018
The safe application of geological carbon storage depends also on the seismic hazard associated with fluid injection. In this regard, we performed friction experiments using a rotary shear apparatus on precut basalts with variable degree of hydrothermal ...
Andrea, Marzoli   +6 more
core   +4 more sources

Practical, Low-Cost Fault Injection Attacks on Personal Smart Devices

open access: yesApplied Sciences, 2022
Fault attacks are traditionally considered under a threat model that assumes the device under test is in the possession of the attacker. We propose a variation on this model.
Shaked Delarea, Yossi Oren
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

A Function-Level Fault Injection and Machine Learning Framework for Reliability Analysis

open access: yesIEEE Access
Fault injection is widely used to evaluate the vulnerability of applications to soft errors. While hardware-level fault injection provides high accuracy, it is costly and complex, whereas software-level approaches are easier to apply but often less ...
Orhan Gunes, Sanem Arslan
doaj   +1 more source

Dynamic Sealing Behavior of Sand Self-Juxtaposition Windows on a Trap-Bounding Fault in a Natural Gas Storage Site

open access: yesLithosphere, 2022
An understanding of across-fault seals is essential for planning an injection/production strategy for a fault-bounded gas storage site. In addition, it is more likely to permit lateral leakage for a fault with sand self-juxtaposition windows.
Xiaoling Zhang   +10 more
doaj   +1 more source

Formalising fault injection and countermeasures

open access: yesProceedings of the 15th International Conference on Availability, Reliability and Security, 2020
Fault injection is widely used as a method to evaluate the robustness and security of a system against many kinds of faults and attacks. Recent works have considered many ways to demonstrate security risks and viable attacks using fault injection, and some have also proposed countermeasures.
Given-Wilson, Thomas   +2 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Research on Intelligent Diagnosis and Decision-Making Method for Oilfield Water Injection System Faults

open access: yesIEEE Access
Water injection is a commonly used development method in oilfields. Water injection systems are large and complex, with horizontally and vertically interconnected pipeline networks often buried underground.
Ruijie Zhang   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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