Results 81 to 90 of about 111,641 (296)

DIFFUSION CHARACTERISTICS OF GROUT IN LAYERED FAULT MEDIUM [PDF]

Civil Engineering Journal, 2018
The grouting method has been widely adopted to improve the soft and broken ground properties in tunnelling engineering. This paper carries out numerical and experimental investigation to study the diffusion characteristics of grout in layered fault ...
Li Peng, Zhang Xiao, Wang Qian, Zhang Qingsong   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Static analysis of SEU effects on software applications [PDF]

, 2002
Control flow errors have been widely addressed in literature as a possible threat to the dependability of computer systems, and many clever techniques have been proposed to detect and tolerate them.
Benso, Alfredo, Di Carlo, Stefano, Di Natale, Giorgio, Prinetto, Paolo Ernesto   +3 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

A Diversity Model Based on Failure Distribution and Its Application in Safety Cases [PDF]

, 2014
This work develops a new basis for evaluating the reliability benefits of diverse software, based on fault injection testing. In particular, the work investigates forms of argumentation that could be used to justify diversity as a basis for the ...
Chen, Luping, May, John H R
core   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Upper bounds on fault tolerance thresholds of noisy Clifford-based quantum computers [PDF]

, 2010
We consider the possibility of adding noise to a quantum circuit to make it efficiently simulatable classically. In previous works, this approach has been used to derive upper bounds to fault tolerance thresholds-usually by identifying a privileged ...
Plenio, M B, Virmani, S.
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Geomechanics modeling of ultra-deep fault-controlled carbonate reservoirs and its application in development

Shiyou shiyan dizhi
To enhance the development efficiency of ultra-deep fault-controlled carbonate reservoirs, large-scale rock mechanical experiments were conducted to reveal the deformation and connectivity mechanisms of high-angle to near-vertical fault surfaces.
Zhenzhong CAI, Hui ZHANG, Ke XU, Guoqing YIN, Zhimin WANG, Haiying WANG, Ziwei QIAN, Yu ZHANG   +7 more
doaj   +1 more source

Principles of Antifragile Software

, 2017
The goal of this paper is to study and define the concept of "antifragile software". For this, I start from Taleb's statement that antifragile systems love errors, and discuss whether traditional software dependability fits into this class. The answer is
Conway M. E., Locasto M. E., Petroski H., Weinberg G. M.   +3 more
core   +2 more sources