Results 91 to 100 of about 20,765 (306)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Fault Location of Generator Stator with Single-Phase High-Resistance Grounding Fault Based on Signal Injection. [PDF]

open access: yesSensors (Basel)
This paper proposes a novel method for locating single-phase grounding faults in generator stator windings with high resistance, which are typically challenging to locate due to weak fault characteristics.
Lei B   +7 more
europepmc   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Locked out by Latch-up? An Empirical Study on Laser Fault Injection into Arm Cortex-M Processors

open access: yes, 2022
S.7-14Laser-based fault injection (LFI) is considered as one of the most powerful tools for active attacks against integrated circuits. However, only few empirical results are published for LFI into modern low-power microcontrollers with current process ...
Koppermann, P.   +5 more
core   +1 more source

Geomechanics modeling of ultra-deep fault-controlled carbonate reservoirs and its application in development

open access: yesShiyou shiyan dizhi
To enhance the development efficiency of ultra-deep fault-controlled carbonate reservoirs, large-scale rock mechanical experiments were conducted to reveal the deformation and connectivity mechanisms of high-angle to near-vertical fault surfaces.
Zhenzhong CAI   +7 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Achieving Representative Faultloads in Software Fault Injection

open access: yes, 2011
Given the complexity of modern software systems and its pervasiveness in many aspects of our lives, software faults (i.e., bugs) are a dangerous threat.
Natella, Roberto
core  

Multi-spot Laser Fault Injection Setup: New Possibilities for Fault Injection Attacks

open access: yes, 2021
International audienceFault injection attacks rely on experimental techniques to inject one or several faults into a device during operation. Among these techniques, laser fault injection is known as a powerful one, thanks to its unmatched spatial and ...
de Laulanié, Lucie   +6 more
core   +1 more source

Measuring Fault Tolerance with the FTAPE fault injection tool [PDF]

open access: yes, 1995
This paper describes FTAPE (Fault Tolerance And Performance Evaluator), a tool that can be used to compare fault-tolerant computers. The major parts of the tool include a system-wide fault injector, a workload generator, and a workload activity measurement tool. The workload creates high stress conditions on the machine.
Timothy K. Tsai, Ravishankar K. Iyer
openaire   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

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