Results 61 to 70 of about 12,124 (305)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Concurrent fault diagnosis of modular multilevel converter with Kalman filter and optimized support vector machine

Systems Science & Control Engineering, 2019
In this paper, concurrent fault diagnosis problem of modular multilevel converter (MMC) with Kalman filter and optimized support vector machine (SVM) is investigated. The state space model by synthesizing the circulating current and the output current is
Yong Zhang, Huanzhen Hu, Zhenxing Liu, Min Zhao, Lei Cheng   +4 more
doaj   +1 more source

Fault location and isolation technology for power grid automation based on intelligent algorithms

Energy Informatics
Background Power grid automation is critical for maintaining the stability and reliability of electrical grids. A major challenge in power grid management is identifying and isolating faults quickly and accurately to avoid widespread disruptions ...
Qi Guo, Fuhe Wang, Suxia Cheng, Ke Wang, Yifan Zhang   +4 more
doaj   +1 more source

Fault Classification and Localization in Power Transmission Lines Using LSTM and Vibration Data Analysis

NTU Journal of Engineering and Technology
The precise classification and localization of faults in power transmission lines are very important to ensure grid stability and to minimize service interruptions. Traditional methods of fault detection frequently have difficulty with complicated fault
Enas Ali Ahmed, Muna Hassan Hussein, Mohammed Talal Ghazal   +2 more
doaj   +1 more source

Spectrum-Based Fault Localization for Diagnosing Concurrency Faults [PDF]

, 2013
Concurrency faults are activated by specific thread interleavings at runtime. Traditional fault localization techniques and static analysis fall short to diagnose these faults efficiently. Existing dynamic fault-localization techniques focus on pinpointing data-access patterns that are subject to concurrency faults. In this paper, we propose a spectrum-
Feyzullah Koca, Hasan Sözer, Rui Abreu 0001   +2 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Spectrum-based Fault Localization Techniques Application on Multiple-Fault Programs: A Review

, 2020
Software fault localization is one of the most tedious and costly activities in program debugging in the endeavor to identify faults locations in a software program. In this paper, the studies that used spectrum-based fault localization (SBFL) techniques
Nura Modi Shagari, Shamsu Abdullahi, Nuruddeen Musa Shanono, Jaafar Zubairu Maitama, Abubakar Zakari, Abubakar Bello Tambawal   +5 more
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