Results 81 to 90 of about 16,975 (265)

Research on fault time prediction method for high speed rail BTM unit based on multi method interactive validation

High-Speed Railway
The Balise Transmission Module (BTM) unit of the on-board train control system is a crucial component. Due to its unique installation position and complex environment, this unit has a higher fault rate within the on-board train control system. To conduct
Limin Fu, Junqiang Gou, Chao Sun, Hanrui Li, Wei Liu   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

EFFECTIVENESS OF FAULT PREDICTION

, 2018
The research community in software engineering is trying to find a way on how to achieve the goal of having a fault-free software. The industry that will use a near fault-free software will have it easier to lower the costs of maintenance and the versions of delivered software will be more qualitative.
openaire   +2 more sources

Fault prediction in distributed systems gone wild

Proceedings of the 4th International Workshop on Large Scale Distributed Systems and Middleware, 2010
We consider the problem of predicting faults in deployed, large-scale distributed systems that are heterogeneous and federated. Motivated by the importance of ensuring reliability of the services these systems provide, we argue that the key step in making these systems reliable is the need to automatically predict faults. For example, doing so is vital
Canini, Marco, Novakovic, Dejan, Jovanovic, Vojin, Kostic, Dejan   +3 more
openaire   +3 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Research on Fault Prediction of Nuclear Safety-Class Signal Conditioning Module Based on Improved GRU

Energies
To improve the reliability and maintainability of the nuclear safety-class digital control system (DCS), this paper conducts a study on the fault prediction of critical components in the output circuit of the nuclear safety-class signal conditioning ...
Zhi Chen, Miaoxin Dai, Jie Liu, Wei Jiang   +3 more
doaj   +1 more source

Software mining and fault prediction

WIREs Data Mining and Knowledge Discovery, 2012
AbstractMining software repositories (MSRs) such as source control repositories, bug repositories, deployment logs, and code repositories provide useful patterns for practitioners. Instead of using these repositories as record‐keeping ones, we need to transform them into active repositories that can guide the decision processes inside the company.
openaire   +2 more sources