Results 81 to 90 of about 445,363 (308)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Research of protection for AC transmission lines based on characteristic of grid-side inverter

open access: yesThe Journal of Engineering, 2019
With the advantage of saving resources and high utilisation, DC transmission becomes the vital part of the sustainable development. However, due to the control strategies of grid-side inverter, the fault characteristics of the grid will change ...
Ning Huang, Chunju Fan, Shan Jiang
doaj   +1 more source

Distributed current sensing technology for protection and fault location applications in HVDC networks [PDF]

open access: yes, 2018
This paper presents a novel concept for a distributed current optical sensing network, suitable for protection and fault location applications in High Voltage Multi-terminal Direct Current (HV-MTDC) networks. By utilising hybrid Fibre Bragg Grating (FBG)-
Booth, Campbell   +5 more
core   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Time domain complete protection scheme for parallel

open access: yesAin Shams Engineering Journal, 2016
In this paper, time domain relaying schemes for complete protection of parallel transmission lines using wavelet and artificial neural network (ANN) are presented.
Aleena Swetapadma, Anamika Yadav
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Faults and unbalance forces in the switched reluctance machine [PDF]

open access: yes, 1995
The paper identifies and analyzes a number of severe fault conditions that can occur in the switched reluctance machine, from the electrical and mechanical points of view.
Miller, T.J.E.
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Quasi-single phase permanent fault identification method and reclosing strategy based on multi-level confidence rules

open access: yesInternational Journal of Electrical Power & Energy Systems
As global temperatures rise, the frequency of lightning increases, making lightning one of the principal threats to power-system security. Field incidents indicate that, within the automatic reclosing time window, multiple-stroke lightning can exhibit ...
Hongchun Shu   +7 more
doaj   +1 more source

Fault detection and isolation [PDF]

open access: yes
Erroneous measurements in multisensor navigation systems must be detected and isolated. A recursive estimator can find fast growing errors; a least squares batch estimator can find slow growing errors. This process is called fault detection. A protection
Bernath, Greg
core   +1 more source

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