Results 51 to 60 of about 10,344 (220)

Role and significance of asprosin in feeding behaviour and metabolism

Кубанский научный медицинский вестник, 2020
This article presents a review of available information on asprosin — a hormone of white adipose tissue discovered in 2016. The history of its discovery, as well as its action mechanisms and main targets are examined.
Rustam H. Salimkhanov, Vladislav R. Sharifullin, Yulia R. Kushnareva, Azamat Kh. Kade, Pavel P. Polyakov   +4 more
doaj   +1 more source

Generation of human induced pluripotent stem cell line UGENTi001-A from a patient with Marfan syndrome carrying a heterozygous c.7754 T > C variant in FBN1 and the isogenic control UGENT001-A-1 using CRISPR/Cas9 editing

Stem Cell Research, 2023
Marfan syndrome is an autosomal dominant genetic disorder resulting from pathogenic variants in FBN1 gene. FBN1 encodes for fibrillin-1, an important extracellular matrix protein.
Jeffrey Aalders, Laurens Léger, Anthony Demolder, Laura Muiño Mosquera, Paul Coucke, Björn Menten, Julie De Backer, Jolanda van Hengel   +7 more
doaj   +1 more source

Targetting of Fbn1.

, 2013
(A) Scheme of Fbn1 targeting. From top to bottom, fibrillin1 protein with the internally deleted region (residues 770–1042); schematic representation of the corresponding Fbn1 gene region with the probes (I and III) used in the Southern-blot analysis ...
Bruno L. Lima (359298), José A. Visintin (359306), Enrico J. C. Santos (359299), Marco R. B. Mello (359302), Marina Soukoyan (359304), Lygia V. Pereira (247926), Alexandre Kerkis (54156), Gustavo R. Fernandes (359300), Juliana P. A. Gomes (359303), Christian Merkel (359301), Silvia M. G. Massironi (359305)   +10 more
core   +1 more source

Hsa_circ_0004674 promotes osteosarcoma doxorubicin resistance by regulating the miR-342-3p/FBN1 axis

Journal of Orthopaedic Surgery and Research, 2021
Background The occurrence of chemoresistance is a common problem in tumor treatment. Circular RNA (circRNA) has been confirmed to be related to tumor chemoresistance.
Yumei Bai, Yanghua Li, Juan Bai, Yumei Zhang   +3 more
doaj   +1 more source

The extracellular matrix glycoprotein fibrillin-1 in health and disease

Frontiers in Cell and Developmental Biology
Fibrillin-1 (FBN1) is a large, cysteine-rich, calcium binding extracellular matrix glycoprotein encoded by FBN1 gene. It serves as a structural component of microfibrils and provides force-bearing mechanical support in elastic and nonelastic connective ...
Li Li, Li Li, Junxin Huang, Junxin Huang, Youhua Liu, Youhua Liu   +5 more
doaj   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Truncated C-terminus of fibrillin-1 induces Marfanoid-progeroid-lipodystrophy (MPL) syndrome in rabbit

Disease Models & Mechanisms, 2018
Various clinical differences have been observed between patients with the FBN1 gene mutation and those with the classical Marfan phenotype. Although FBN1 knockout (KO) or dominant-negative mutant mice are widely used as an animal model for Marfan ...
Mao Chen, Bing Yao, Qiangbing Yang, Jichao Deng, Yuning Song, Tingting Sui, Lina Zhou, HaoBing Yao, Yuanyuan Xu, Hongsheng Ouyang, Daxin Pang, Zhanjun Li, Liangxue Lai   +12 more
doaj   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Caracterização genotípica de uma população de doentes portugueses com síndrome de Marfan

Revista Portuguesa de Cardiologia, 2011
Resumo: Introdução: O diagnóstico da Síndrome de Marfan (SM) depende fundamentalmente de uma avaliação clínica multidisciplinar. O seu diagnóstico molecular, através da identificação de mutações no gene FBN1, pode permitir estabelecer um diagnóstico ...
Ana Lebreiro, Elisabete Martins, Cristina Cruz, Jorge Almeida, Sofia Pimenta, Miguel Bernardes, José Carlos Machado, M. Júlia Maciel, Cassiano Abreu-Lima   +8 more
doaj   +1 more source

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source