Results 61 to 70 of about 2,855 (182)
ABSTRACT Background/Purpose Visible light (VL), and particularly high‐energy visible light (HEVL), reaching Earth's surface has emerged as a relevant contributor to skin damage. VL has been implicated in oxidative stress, inflammation, pigmentation disorders, and photoaging, especially in individuals with darker skin phototypes.
Azahara Rodríguez‐Luna +5 more
wiley +1 more source
Background: Birt-Hogg-Dubé (BHD) syndrome and congenital contractural arachnodactyly (CCA) or Beals-Hecht syndrome are clinically rare autosomal dominant genetic diseases.
Jiayong Qiu +7 more
doaj +1 more source
ABSTRACT Canine mammary gland tumours (MGT) represent a common malignancy in intact female dogs, with a high metastasis rate approaching 50% and a poor prognosis. However, metastasis‐related genes remain largely unelucidated. Accordingly, we aimed to identify differentially expressed mRNAs and miRNAs in primary canine MGT tissues from dogs with or ...
Shaohsu Wang +14 more
wiley +1 more source
Characterization of a Plastoglobule-Localized SOUL4 Heme-Binding Protein in Arabidopsis thaliana
Heme plays an active role in primary plant metabolic pathways as well as in stress signaling. In this study, we characterized the predicted heme-binding protein SOUL4.
Venkatasalam Shanmugabalaji +2 more
doaj +1 more source
Therapeutic and Predicted Significance of PKLR in Patients With Cholangiocarcinoma
ABSTRACT Background Cholangiocarcinoma (CCA) is a highly heterogeneous malignancy with a poor prognosis. However, the molecular mechanisms underlying CCA and its treatment options remain unclear and limited. Aims This study aims to identify novel prognostic biomarkers and potential therapeutic targets for CCA through transcriptomics and whole‐exome ...
Biyan Gong +7 more
wiley +1 more source
Forelimb contractures, reduced muscle mass and altered muscle morphology in P0 Fbn2 null mice.
(A)Fbn2 null forelimb contractures from P0 to P8. (B) Representative H&E stained P0 forearm cross sections from the same approximate position in the forearm. The cross sections are composites of multiple micrographs.
Francesco Ramirez (22223) +8 more
core +1 more source
Mutation Analysis of Fibrillin-2 (FBN2) and Microfibril Associated Protein-3 (MFAP-3): Two Genes Associated with Congenital Contractural Arachnodactyly (CCA), also known as Beal\u27s Syndrome [PDF]
Congenital Contractural Arachnodactyly (CCA), also known as Beal\u27s syndrome, is an autosomal dominant disorder characterized by multiple congenital joint contractures, arachnodactyly, dolichostenomelia, and scoliosis with only rare ocular or ...
Babcock, Darcie
core +1 more source
Hydrogel culture mimicking young and aged ovarian stromal stiffness recapitulates key features of reproductive aging, including impaired follicle growth, transzonal projections (TZPs), and oocyte quality. Silencing Smad7 rescues TZPs and oocyte quality in stiff hydrogels, identifying ECM mechanics as a driver and therapeutic target in ovarian aging ...
Xingyu Shen +10 more
wiley +1 more source
MyGene2 automated match report: FBN2
MyGene2.org is free, public, searchable & browsable website. Families with rare genetic conditions, clinicians, and researchers families who are interested in sharing health and genetic information can create MyGene2 profiles and use these to connect with other families, clinicians, and researchers who may have or be studying the same condition. If
openaire +1 more source
Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging. [PDF]
Animal genomes are folded into loops and topologically associating domains (TADs) by CTCF and loop-extruding cohesins, but the live dynamics of loop formation and stability remain unknown. Here, we directly visualized chromatin looping at the Fbn2 TAD in
Hansen, Anders S +23 more
core +1 more source

