Results 71 to 80 of about 2,855 (182)

Delineation of a new fibrillino-2-pathy with evidence for a role of FBN2 in the pathogenesis of carpal tunnel syndrome

, 2020
BACKGROUND: Although carpal tunnel syndrome (CTS) is the most common form of peripheral entrapment neuropathy, its pathogenesis remains largely unknown.
Vandeweyer, Geert, Boudin, Eveline, Van Hul, Wim, Fransen, Erik, Lammens, Martin, Cain, Stuart Alan; id_orcid, Houpt, Peter, Noyez, Jan, Cain, Stuart Alan, Kumar, Ajay, Kumar, Ajay Anand, Hermans, Christophe, Mortier, Geert, Jacobs, Werner, Verstreken, Frederik, Decramer, Arne, Peeters, Silke, Baldock, Clair, Loeys, Bart   +18 more
core   +1 more source

A novel FBN2 mutation cosegregates with congenital contractural arachnodactyly in a five‐generation Chinese family

Clinical Case Reports, 2018
Key Clinical Message We identified a novel heterozygous mutation (c.4177T>G and p.Cys1393Gly) in FBN2 that cosegregated with congenital contractural arachnodactyly (CCA) in a five‐generation Chinese family.
Shiyuan Zhou, Fengyu Wang, Yongheng Dou, Jiping Zhou, Gefang Hao, Chengqi Xu, Qing K. Wang, Haili Wang, Pengyun Wang   +8 more
doaj   +1 more source

Identification of an Epigenetic Signature for Coronary Heart Disease in Postmenopausal Women’s PBMC DNA

Mediators of Inflammation, 2022
Menopause is accompanied with an increased risk of cardiovascular disease. DNA methylation may have a significant impact on postmenopausal women’s development of coronary heart disease.
Xiao Zhong, Ziguang Song, Pingping Gao, Mingyang Li, Zhongping Ning, Xiang Song   +5 more
doaj   +1 more source

From Gut to Fat: Intestinal Epithelial Exosomes Target PDGFRα+ Progenitors to Promote Lipogenesis and Counteract Subcutaneous Adipose Tissue Atrophy in Aging

Aging Cell, Volume 25, Issue 7, July 2026.
Young small intestinal epithelial‐derived exosomes (young‐SI‐Exos) deliver miR‐379‐5p, which targets Usp34 to suppress the Wnt/β‐catenin pathway, thereby promoting adipocyte differentiation, enhancing lipid metabolism, and increasing lipid droplets in PDGFRα+ progenitors, ultimately reversing age‐related subcutaneous adipose tissue (SAT) atrophy ...
Tingting Huang, Ye Huang, Yin Zhou, Xuanbei Lu, Lijun Yang, Jing Yu, Yunlu Sheng, Fan Xia, Guoxian Ding, Yifan Lv, Shan Lv   +10 more
wiley   +1 more source

BMP signaling in wildtype and Fbn2 null forearm muscle.

, 2015
(A) Phosphosmad 1/5/8 immunofluorescence signals (green dots) within DAPI blue-stained nuclei of Fbn2 null muscle compared to wildtype at P1 and P8. (B)BMP mRNA expression levels in P0 Fbn2 heterozygous and null muscle compared to wildtype.
Francesco Ramirez (22223), Valerie Carlberg (761367), Eric J. Carlson (189254), Douglas R. Keene (46430), Lynn Y. Sakai (189267), Sara F. Tufa (189251), Noe L. Charbonneau (189257), Silvia Smaldone (22222), Gerhard Sengle (189245)   +8 more
core   +1 more source

Screening and expression validation of key proteins for secondary hair follicle growth in cashmere goats based on iTRAQ quantitative proteomics technology

Frontiers in Veterinary Science
BackgroundThe growth of secondary hair follicles (SHFs) in cashmere goats has periodic changes, including telogen, anagen, and catagen, during which proteins play important roles as the executor of life activities.ResultsIn this study, the skin tissues ...
Jiale Chang, Jiale Chang, Fanhua Meng, Fanhua Meng, Ru Zhang, Ru Zhang, Juan Feng, Juan Feng, Yujing Liu, Yujing Liu, Junjie Zhang, Junjie Zhang, Zhaomin Liu, Zhaomin Liu, Jiayue Liang, Hongmei Xiao, Hongmei Xiao   +16 more
doaj   +1 more source

Light‐Inducible Activation of FGFR3 Facilitates Chondrocyte Maturation

Cell Proliferation, Volume 59, Issue 7, July 2026.
Light‐inducible activation of FGFR3 induced robust activation of MAPK signaling, promoting proliferation and collagen depositon in induced chondrocytes and prevent the degeneration of osteoarthritic chondrocytes.
Mengze Sun, Yun Zhao, Yuqing Du, Yifei Fan, Kai Wang, Xiaoqing Hu   +5 more
wiley   +1 more source

Establishment of a Beals syndrome patient-derived human induced pluripotent stem cell line HELPi001-A

Stem Cell Research, 2019
The human induced pluripotent stem cell line HELPi001-A was derived from peripheral blood mononuclear cells (PBMC) of a 35-year-old female Beals syndrome patient carrying a heterozygous FBN2c.728 T > C mutation.
Hao Liu, Yatping Tsui, Jiaxian Wang, Chen Su, Rui Zheng, Yongfeng Shao, Buqing Ni   +6 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Clinical and genetic data of 7 patients with FBN2 c.3769T>C (p.C1257R) mutation.

, 2016
Clinical and genetic data of 7 patients with FBN2 c.3769T>C (p.C1257R) mutation.
Lamei Yuan (748098), Yi Guo (35817), Xiong Deng (429533), Hongbo Xu (748097), Liping Guan (420348), Zhi Song (429534), Hao Deng (409186), Jingjing Xiao (491533), Qian Lu (387695), Zhijian Yang (217065), Qiongfen Lin (2795020)   +10 more
core   +1 more source