Results 211 to 220 of about 446,586 (304)

Pharmacokinetics and Pharmacodynamics of Nipocalimab, a Neonatal Fc Receptor Blocker, in Healthy Japanese Volunteers. [PDF]

Clin Drug Investig
Matsushima N, Shibata S, Leu JH, Vermeulen A, Duffner J, Ling LE, Schwartz LB, Harigae H.   +7 more
europepmc   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

Current state and potential applications of neonatal Fc receptor (FcRn) inhibitors in hematologic conditions. [PDF]

Am J Hematol
Jacobs JW, Booth GS, Raza S, Clark LM, Fasano RM, Gavriilaki E, Abels EA, Binns TC, Duque MA, McQuilten ZK, Mingot-Castellano ME, Savani BN, Sharma D, Tran MH, Tormey CA, Moise KJ, Bloch EM, Adkins BD.   +17 more
europepmc   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Baicalein Ameliorates Experimental Ulcerative Colitis Recurrency by Downregulating Neonatal Fc Receptor via the NF-κB Signaling Pathway. [PDF]

ACS Omega
Hu H, Lu F, Guan X, Jiang X, Wen C, Wang L.   +5 more
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Influence of Distinct Maternal Cytomegalovirus-Specific Neutralizing and Fc Receptor-Binding Responses on Congenital Cytomegalovirus Transmission in HIV-Exposed Neonates. [PDF]

Viruses
Miller IG, Mahant AM, Jenks JA, Semmes EC, Rochat E, Herbek SL, Andy C, Rodgers NS, Pollara J, Gerber LM, Herold BC, Permar SR.   +11 more
europepmc   +1 more source

Structural basis for Fc receptor recognition of immunoglobulin M

, 2022
Chen Q, Menon R, Tolar P, Rosenthal PB.
europepmc   +1 more source

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

Advanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang, Ya‐Ning Wang, Da Lin, Jia‐Yang Xu, Feng‐Yuan Qi, Hui‐Ling Cui, Hui‐Jie Lu, Min Qiao, Edward Topp, Dong Zhu, Matthias C. Rillig, Yong‐Guan Zhu   +11 more
wiley   +1 more source

Increased SARS-CoV-2 IgG4 has variable consequences dependent upon Fc function, Fc receptor polymorphism, and viral variant. [PDF]

Sci Adv
Aurelia LC, Purcell RA, Theisen RM, Kelly A, Esterbauer R, Ramanathan P, Lee WS, Wines BD, Hogarth PM, Juno JA, Allen LF, Bond KA, Williamson DA, Trevillyan JM, Trubiano JA, Nguyen TH, Kedzierska K, Wheatley AK, Kent SJ, Arnold KB, Selva KJ, Chung AW.   +21 more
europepmc   +1 more source