Results 101 to 110 of about 10,163 (201)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

A Physiologically Based Pharmacokinetic Model Relates the Subcutaneous Bioavailability of Monoclonal Antibodies to the Saturation of FcRn-Mediated Recycling in Injection-Site-Draining Lymph Nodes

Antibodies
The bioavailability of a monoclonal antibody (mAb) or another therapeutic protein after subcutaneous (SC) dosing is challenging to predict from first principles, even if the impact of injection site physiology and drug properties on mAb bioavailability ...
Felix Stader, Cong Liu, Abdallah Derbalah, Hiroshi Momiji, Xian Pan, Iain Gardner, M. Jamei, Armin Sepp   +7 more
semanticscholar   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Population Pharmacokinetics of Clesrovimab in Preterm and Full‐Term Infants

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1036-1046, April 2026.
Clesrovimab is a half‐life extended monoclonal antibody targeting the respiratory syncytial virus fusion protein. Three studies (phase Ib/IIa [MK‐1654‐002], phase IIb/III [CLEVER], and phase III [SMART]) were conducted to evaluate the efficacy, safety, and pharmacokinetics (PK) of clesrovimab in infants.
Ziheng Hu, Farina Hellmann, Xiaowei Zang, Nele Plock, Keyur Parmar, Radha A. Railkar, S. Y. Amy Cheung, Brian M. Maas, Ferdous Gheyas   +8 more
wiley   +1 more source

COVID‐19 and Pregnancy: Key Findings

Scandinavian Journal of Immunology, Volume 103, Issue 4, April 2026.
Mechanistic overview of maternal SARS‐CoV‐2 immunisation, affinity‐matured IgG production, FcRn‐mediated transplacental IgG transport, and antibody delivery to the newborn via fetal circulation and breast milk. The schematic also highlights the translational relevance of murine models, which share conserved mechanisms of antibody induction despite ...
Gabrielle Gimenes Lima, Ana Flávia Segati, Giovanna Santos Oliveira, Nicoly Simões de Melo, Túlio Nakazato da Cunha, Elizabeth De Gaspari   +5 more
wiley   +1 more source

Localization of neonatal Fc receptor for IgG in aggregated lymphoid nodules area in abomasum of Bactrian camels (Camelus bactrianus) of different ages

BMC Veterinary Research, 2016
Background The neonatal Fc receptor (FcRn) plays a crucial role in transporting IgG and associated antigens across polarized epithelial barriers in mucosal immunity. However, it was not clear that FcRn expression in aggregated lymphoid nodules area (ALNA)
Wang-Dong Zhang, Wen-Hui Wang, Shu-Xian Li, Shuai Jia, Xue-Feng Zhang, Ting-Ting Cao   +5 more
doaj   +1 more source

FcRn antagonists in ITP

Annals of Blood, 2021
Adrian C. Newland, Vickie McDonald
openaire   +1 more source

Daratumumab Treatment for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP): A Case Report

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 622-626, March 2026.
ABSTRACT Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune‐mediated neuropathy featuring progressive weakness, sensory deficits, and areflexia. While corticosteroids, intravenous immunoglobulin, and plasmapheresis are effective first‐line immunotherapies, a subset of patients remains treatment‐refractory.
Xueyu Zhang, Jianli Zhao, Xue Zhao, Xiaowei Hu, Zichun Xiao, Jie Wu, Xiaowen Li, Jing Xu, Yu‐Jing Li   +8 more
wiley   +1 more source

Double‐Filtration Plasmapheresis Versus Efgartigimod for Generalized Myasthenia Gravis: Severity‐Stratified Benefits in a Prospective Observational Multicenter Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Both Double‐Filtration Plasmapheresis (DFPP) and efgartigimod effectively treat acute exacerbations of generalized myasthenia gravis (gMG), with efficacy rising across successive sessions. In moderate‐to‐severe gMG, 3/5‐session DFPP outperformed 4‐infusion efgartigimod, while efficacy was comparable in mild cases.
Kan Wang, Hanyu Xin, Mengze Zhang, Qiuju Li, Yanan Wu, Xia Li, Jing Peng, Chong Xie, Xiajun Zhou, Li Gao, Xuzhong Pei, Yiwei Yang, Yuhui Wang, Yuan Zhong, Lu Zhang, Desheng Zhu, Yangtai Guan   +16 more
wiley   +1 more source

Binding of therapeutic Fc-fused factor VIII to the neonatal Fc receptor at neutral pH associates with poor half-life extension

Haematologica
Fusion of therapeutic proteins to the Fc fragment of human IgG1 promotes their FcRn-mediated recycling and subsequent extension in circulating half-life.
Alejandra Reyes-Ruiz, Sandrine Delignat, Aishwarya Sudam Bhale, Victoria Daventure, Robin V. Lacombe, Leslie Dourthe, Olivier Christophe, Sune Justesen, Krishnan Venkataraman, Jordan D. Dimitrov, Sebastien Lacroix-Desmazes   +10 more
doaj   +1 more source