Results 111 to 120 of about 10,163 (201)

Ninjurin1 in cardiovascular and vascular biology: From molecular mechanisms to therapeutic opportunities

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
NINJ1 mediates PMR in cardiovascular cell death, releasing DAMPs that amplify vascular inflammation. Dual NINJ1 paradox: membrane‐bound form drives endothelial NF‐κB/CXCL‐8 inflammation while soluble form provides atheroprotection. Pericyte NINJ1 regulates the critical balance between angiogenic sprouting and vessel maturation in ischaemic tissues ...
Muhammad Mamunur Rashid Mahib
wiley   +1 more source

Transcriptome–Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass‐Specific Phenotypes

European Journal of Immunology, Volume 56, Issue 3, March 2026.
We performed combined proteome and transcriptome analysis of human isotype‐defined B cell subsets. IgG4‐switched B cells were most distinct from naive B cells in terms of mRNA as well as protein expression profiles. SDR16C5 was identified as uniquely upregulated in IgG4‐switched B cells.
Jana Koers, Arie J. Hoogendijk, Simon Tol, Floris P.J. Van Alphen, Ninotska I.L. Derksen, Maartje van den Biggelaar, Theo Rispens   +6 more
wiley   +1 more source

Reshaping study design for faster extrapolation‐based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN–NASPGHAN position paper

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 3, Page 867-894, March 2026.
Abstract Children with inflammatory bowel diseases (IBD) have limited access to the available advanced therapies, given the lengthy gap between adult and pediatric approval. We aimed to review key hurdles for pediatric trials and recommend practical solutions.
Dan Turner, Amit Assa, Mikkel Malham, Shira Yuval Bar‐Asher, Carla Rayan, Jeffrey S. Hyams, Holm H. Uhlig, Brad Pasternak, David C. Wilson, Hilary K. Michel, Lissy de Ridder, Eric Zuckerman, Marina Aloi, Peter Szitanyi, Marla C. Dubinsky, Anne M. Griffiths, Roberto Saldana, Javier Martín‐de‐Carpi, Eytan Wine, Richard K. Russell, Jeremy Adler, Joseph Picoraro   +21 more
wiley   +1 more source

QX008N, an Anti‐TSLP Monoclonal Antibody: Pharmacokinetics, Tolerability, and Immunogenicity in Healthy Chinese Subjects

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT QX008N, a humanized IgG1 monoclonal antibody against thymic stromal lymphopoietin (TSLP) with Fc engineering to extend half‐life, was developed with the aim of exploring whether its extended half‐life and cost‐effective production could potentially address unmet needs in severe asthma therapy, such as the need for less frequent dosing and ...
Zhen‐Wei Shen, Qi Jiang, Kai‐Qi Wu, Ting‐Han Jin, Jie Zhao, Tong Guo, Min Fang, Gui‐Ling Chen   +7 more
wiley   +1 more source

Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation

Communications Biology
IgGs have become successful drug scaffolds by combining specific target binding with the ability to induce cellular cytotoxicity. Furthermore, IgGs possess unusually long half-lives in the blood (2-3 weeks).
Esben Trabjerg, Jeannette Nilsen, Torleif Tollefsrud Gjølberg, Jan Terje Andersen, Alexander Leitner, Kasper D. Rand   +5 more
doaj   +1 more source

Minimal Symptom Expression in Generalized Myasthenia Gravis: A Valuable Patient‐Centric Treatment Goal

European Journal of Neurology, Volume 33, Issue 3, March 2026.
Conceptual framework supporting Minimal Symptom Expression (MSE) as a patient‐centric treatment goal in generalized myasthenia gravis. Guidelines prioritize minimal manifestations (MM) or better (MGFA‐PIS); MM is clinician‐judgment based and not instrument‐defined. MSE (MG‐ADL 0‐1) is standardized, actionable, and widely used. Across Phase III programs
Andreas Meisel, Akiyuki Uzawa, Cynthia Z. Qi, Dustin Nowacek, Jeff Guptill, James F. Howard Jr   +5 more
wiley   +1 more source

A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

CPT: Pharmacometrics & Systems Pharmacology, 2019
Monoclonal antibody (mAb) pharmacokinetics (PK) have largely been predicted via allometric scaling with little consideration for cross‐species differences in neonatal Fc receptor (FcRn) affinity or clearance/distribution mechanisms.
Hannah M. Jones, Zhiwei Zhang, Paul Jasper, Haobin Luo, Lindsay B. Avery, Lindsay E. King, Hendrik Neubert, Hugh A. Barton, Alison M. Betts, Robert Webster   +9 more
doaj   +1 more source

Phase 2 study of efgartigimod, a novel FcRn antagonist, in adult patients with primary immune thrombocytopenia

American journal of hematology/oncology, 2019
Primary immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder, characterized by a low platelet count (
A. Newland, B. Sánchez‐González, L. Rejtő, M. Egyed, N. Romanyuk, M. Godar, K. Verschueren, D. Gandini, P. Ulrichts, J. Beauchamp, T. Dreier, E. Ward, M. Michel, H. A. Liebman, H. Haard, N. Leupin, D. Kuter   +16 more
semanticscholar   +1 more source

Artificial lipidation of proteins and peptides: from mechanism to clinical applications

The FEBS Journal, Volume 293, Issue 5, Page 1269-1284, March 2026.
Artificial lipidation transforms protein and peptide therapeutics by attaching fatty acid chains through reversible or permanent chemical strategies. This biomimetic approach delivers four key therapeutic advantages: extended circulation times (enabling weekly instead of daily dosing), alternative administration routes including oral delivery, precise ...
Jiaming Mu, Emily Vong, Sheiliza Carmali
wiley   +1 more source

FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques

mAbs
Prenatal administration of monoclonal antibodies (mAbs) is a strategy that could be exploited to prevent viral infections during pregnancy and early life.
Joanna Zikos, Gabriela M. Webb, Helen L. Wu, Jason S. Reed, Jennifer Watanabe, Jodie L. Usachenko, Ala M. Shaqra, Celia A. Schiffer, Koen K. A. Van Rompay, Jonah B. Sacha, Diogo M. Magnani   +10 more
doaj   +1 more source