Advances in Inhaled Nanoparticle Drug Delivery for Pulmonary Disease Management
The FASEB Journal, Volume 39, Issue 21, 15 November 2025.Pulmonary disorders remain a global health challenge. This review explores critical innovations in inhaled nanoparticle drug delivery systems focusing on their potential to revolutionize treatment strategies for a wide spectrum of pulmonary diseases. We highlight recent breakthroughs in carrier materials, performance evaluations in vitro and in vivo ...
Yunzhou Fan +3 more
wiley +1 more source
FcRn expression in cancer: Mechanistic basis and therapeutic opportunities
, 2021 Imke Rudnik‐Jansen, Kenneth A. Howard
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Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of immune-mediated kidney disease [PDF]
, 2020 James Dylewski +4 more
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CPT: Pharmacometrics & Systems Pharmacology, 2019 Monoclonal antibody (mAb) pharmacokinetics (PK) have largely been predicted via allometric scaling with little consideration for cross‐species differences in neonatal Fc receptor (FcRn) affinity or clearance/distribution mechanisms.
Hannah M. Jones +9 more
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FcRn Expression on Placenta and Fetal Jejunum during Early, Mid-, and Late Gestation in Minipigs [PDF]
, 2015 Björn Jacobsen +4 more
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SkinNet: A Deep Learning Framework for Skin Lesion Segmentation
, 2018 There has been a steady increase in the incidence of skin cancer worldwide, with a high rate of mortality. Early detection and segmentation of skin lesions are crucial for timely diagnosis and treatment, necessary to improve the survival rate of patients.
Maier, Andreas +2 more
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A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques [PDF]
, 2020 Human infection by Zika virus (ZIKV) during pregnancy can lead to vertical transmission and fetal aberrations, including microcephaly. Prophylactic administration of antibodies can diminish or prevent ZIKV infection in animal models, but whether passive ...
Agudelo, Marianna +25 more
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Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles
CellsResearch into the neonatal Fc receptor (FcRn) has increased dramatically ever since Simister and Mostov first purified a rat version of the receptor.
George Haddad, Judith Blaine
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The First Randomized, Double-Blind, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of an FcRn Inhibitor, Rozanolixizumab, in Patients With Leucine-Rich Gliomainactivated 1 Autoimmune Encephalitis [PDF]
, 2022 Divyanshu Dubey +4 more
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, 2017 We study the problem of single-image depth estimation for images in the wild. We collect human annotated surface normals and use them to train a neural network that directly predicts pixel-wise depth. We propose two novel loss functions for training with
Chen, Weifeng, Deng, Jia, Xiang, Donglai
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