Results 111 to 120 of about 8,114 (214)

Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration [PDF]

, 2018
Bryan Smith, Andrea Kießling, Rocío Lledó‐García, Kate L. Dixon, Louis Christodoulou, Matthew C. Catley, Paul Atherfold, Lena E. D’Hooghe, Helene M. Finney, Kevin Greenslade, Hanna Hailu, Lara Kevorkian, Daniel Lightwood, Christoph Meier, Rebecca Munro, Omar Qureshi, Kaushik Sarkar, Sophie P. Shaw, Roohi Tewari, Alison Turner, Kerry Tyson, Shauna West, Stevan Shaw, Frank R. Brennan   +23 more
openalex   +1 more source

Evaluation of ASC as a therapeutic target for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract Neuroinflammation is increasingly recognized as a central contributor to the pathogenesis and progression of Alzheimer's disease (AD). The apoptosis‐associated speck‐like protein containing a CARD (ASC), encoded by the PYCARD gene, plays a critical role in the formation of multiple inflammasomes, including NLRP3, a key mediator of inflammation
W. Brent Clayton, Joshua A. Kulas, Jiahui Liu, Nidhi Walia, Claudia Rangel‐Barajas, Travis Johnson, Jie Zhang, Kun Huang, Andrew D. Mesecar, Jeffrey L. Dage, Bruce T. Lamb, Alan D. Palkowitz, Timothy I. Richardson   +12 more
wiley   +1 more source

Development and External Validation of a Multivariable Model to Predict Early Minimal Symptom Expression Response in Adult Generalized Myasthenia Gravis Patients Treated With Efgartigimod

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
A multicenter adult gMG cohort from five tertiary centers in China (N = 118) received efgartigimod 10 mg/kg IV weekly × 4. Early minimal symptom expression (MSE) response was defined as MG‐ADL ≤ 1 sustained ≥ 4 weeks and assessed within 4 weeks. A three‐factor nomogram (bulbar MG‐ADL subscore, FVC% predicted, serum IgG) was developed in the derivation ...
Yufang Yang, Tao Liang, Mingming Zhao, Hongxia Yang, Zhilan Zhao, Lu Yu, Linlin Yan, Siyuan Li, Peng Zhang, Guoyan Qi, Jian Yin, Zucai Xu, Zhong Luo   +12 more
wiley   +1 more source

Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models [PDF]

, 2020
Delphine Valente, Christine Mauriac, Thorsten Schmidt, Ingo Focken, Jochen Beninga, Brian C. Mackness, Huawei Qiu, Pascale Vicat, Abdullah Kandira, Katarina Radošević, Srini Rao, John F. Darbyshire, Mostafa Kabiri   +12 more
openalex   +1 more source

Foundational Principles for the Quantitative Translation of T‐Cell Therapeutics for Hematologic Malignancies and Immunology

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 33-45, January 2026.
T‐cell engaging antibodies (TCEs) and chimeric antigen receptor (CAR) T cells (CAR‐T cells) are among precision medicine therapies that have revolutionized the treatment of hematologic cancers. Their success in oncology has piqued interest in translating this promise into additional indications, such as autoimmune disorders.
Peter Ashcroft, Sarah McFann, Alex Ferguson, Arthur Van De Vyver, Suzanne Gaudet, Eshita Khera, Jan‐Frederik Schlender   +6 more
wiley   +1 more source

FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines

npj Vaccines
Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies (mAb) to target antigen to specific DC subsets.
Christophe Macri, Matthew Paxman, Devi Jenika, Xiao Peng Lin, Zahra Elahi, Paul A. Gleeson, Irina Caminschi, Mireille H. Lahoud, Jose A. Villadangos, Justine D. Mintern   +9 more
doaj   +1 more source

FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques

mAbs
Prenatal administration of monoclonal antibodies (mAbs) is a strategy that could be exploited to prevent viral infections during pregnancy and early life.
Joanna Zikos, Gabriela M. Webb, Helen L. Wu, Jason S. Reed, Jennifer Watanabe, Jodie L. Usachenko, Ala M. Shaqra, Celia A. Schiffer, Koen K. A. Van Rompay, Jonah B. Sacha, Diogo M. Magnani   +10 more
doaj   +1 more source

Dissecting infant and maternal antibody repertoires exposes the early onset of infant humoral immunity

Clinical &Translational Immunology, Volume 15, Issue 1, 2026.
Can we dissect the newborn's own humoral antibody repertoire from the bulk it receives from its mother through placenta (IgG) or through breastfeeding (IgA)? Yes we can! We show that both IgA1 and IgG1 showed unique, infant‐produced clones at 7–11 weeks after birth, not found in maternal serum or breastmilk. Abstract Objectives The early development of
Albert Bondt, Minjie Tan, Kelly A Dingess, Danique MH van Rijswijck, Yuexiao Chen, Shuai Zhu, Ye Tian, Tianhui Lin, Yuanzhen Zhang, Yanyi Huang, Guanbo Wang, Jing Zhu, Juanjuan Guo, Albert JR Heck   +13 more
wiley   +1 more source

Clinical and Biochemical Factors Associated With Infliximab Pharmacokinetics in Adult Patients With Inflammatory Bowel Disease

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Many patients with inflammatory bowel disease (IBD) do not adequately respond to infliximab, potentially due to individual differences in pharmacokinetics (PK). This study aimed to identify clinical and biochemical variables associated with infliximab PK.
Ilse A. Pool, Ilse Volkerink, Mirthe Stavast, Jos G. W. Kosterink, Gerard Dijkstra, Paola Mian, Arno R. Bourgonje   +6 more
wiley   +1 more source

A Rational Approach to Pharmacotherapy in Pregnancy

The Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Most pregnant individuals are exposed to at least one medication, whether prescription or over the counter, during pregnancy. Despite the ubiquity of medication use in pregnancy, there remains no standardized framework to guide clinicians in selecting the most appropriate pharmacotherapy that balances maternal needs with fetal safety. This gap
Gregory W. Kirschen, Kevin Watt, Ahizechukwu C. Eke   +2 more
wiley   +1 more source