Results 181 to 190 of about 10,163 (201)

Effect of FcRn Binding on Monoclonal Antibody Disposition in the Brain

AAPS Journal
This study investigates the role of FcRn in brain disposition of monoclonal antibodies. Human FcRn (hFcRn) expressing mice and different FcRn binding variants of a non-target binding antibody trastuzumab (WT) were used for the investigation.
H. Huang, Shengjia Wu, Shufang Liu, Dhaval K. Shah   +3 more
semanticscholar   +1 more source

FcRn-dependent IgG accumulation in adipose tissue unmasks obesity pathophysiology.

Cell Metabolism
Immunoglobulin G (IgG) is traditionally recognized as a plasma protein that neutralizes antigens for immune defense. However, our research demonstrates that IgG predominantly accumulates in adipose tissue during obesity development, triggering insulin ...
Lexiang Yu, Y. Yang, Zhen Gong, Qianfen Wan, Yifei Du, Qiuzhong Zhou, Yang Xiao, Tarik Zahr, Zhaobin Wang, Zhewei Yu, Kangkang Yang, Jin Geng, Susan K. Fried, Jing Li, Rebecca A. Haeusler, Kam W. Leong, Lin Bai, Yingjie Wu, Lei Sun, Pan Wang, B. Zhu, Liheng Wang, Li Qiang   +22 more
semanticscholar   +1 more source

Early deterioration of CIDP following transition from IVIG to FcRn inhibitor treatment.

Journal of Neurological Sciences
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an immune mediated demyelinating neuropathy that can lead to secondary axonal degeneration and irreversible weakness and disability.
Todd Levine, S. Muley
semanticscholar   +1 more source

FcRn inhibitors: Transformative advances and significant impacts on IgG-mediated autoimmune diseases.

Autoimmunity Reviews
Pathogenic IgG autoantibodies play a crucial role in the pathogenesis of autoimmune diseases, and removal of pathogenic IgG autoantibodies is an important therapeutic approach and tool for such diseases. The neonatal Fc receptor (FcRn) interacts with IgG
Lina Zhu, Lanjun Li, Jun Wu
semanticscholar   +1 more source

Multiple roles of FcRn

1998
FcRn is named for the source from which it was first purified, the intestinal epithelium of neonatal rats. Long before the receptor was characterized it was known that rats and mice acquire maternal antibodies by suckling [reviewed in Reference 1].
openaire   +1 more source

Novel Therapeutic Approach for Psoriasis: Upregulating FcRn to Inhibit Ferroptosis and Alleviate Lesional skin.

Free Radical Biology & Medicine
Psoriasis, a chronic inflammatory skin disease, is characterized by complex immune dysregulation and oxidative stress responses. The neonatal Fc receptor (FcRn) plays a crucial role in the development of autoimmune diseases.
Shaoju Qian, Zishan Yang, Xingyi Zhang, Ruixue Li, Yujie Sun, Zihan Zhang, Yeqing He, Yihang Song, Zhou Tang, Junrui Ding, Shuao Lu, Lili Yu, Xiangfeng Song, Zhinan Yin, Zhongwei Tian   +14 more
semanticscholar   +1 more source

Effect of Individual Fc Methionine Oxidation on FcRn Binding: Met252 Oxidation Impairs FcRn Binding More Profoundly than Met428 Oxidation

Journal of Pharmaceutical Sciences, 2015
The long serum half-lives of mAbs are conferred by pH-dependent binding of IgG-Fc to the neonatal Fc receptor (FcRn). The Fc region of human IgG1 has three conserved methionine residues, Met252, Met358, and Met428. Recent studies showed oxidation of these Met residues impairs FcRn binding and consequently affects pharmacokinetics of therapeutic ...
Xuan, Gao, Junyan A, Ji, Karthik, Veeravalli, Y John, Wang, Taylor, Zhang, William, Mcgreevy, Kai, Zheng, Robert F, Kelley, Michael W, Laird, Jun, Liu, Mary, Cromwell   +10 more
openaire   +2 more sources

Application of FcRn Binding Assays to Guide mAb Development

Drug Metabolism and Disposition, 2014
Monoclonal antibodies (mAbs) represent an important class of therapeutic modalities. To optimize their pharmaceutical properties, studies have focused on improving mAb pharmacokinetic/pharmacodynamic profiles by modulating their interactions with the neonatal Fc receptor (FcRn).
Amita, Datta-Mannan, Victor J, Wroblewski   +1 more
openaire   +2 more sources

Perspective – FcRn transports albumin: relevance to immunology and medicine

Trends in Immunology, 2006
Recent evidence validates a forgotten 40-year-old hypothesis: the MHC-related Fc receptor for IgG (FcRn) protects albumin from intracellular catabolic degradation, as it does for IgG, accounting for the uniquely long half-lives of both molecules and explaining their direct concentration-catabolism relationships.
Clark L, Anderson, Chaity, Chaudhury, Jonghan, Kim, C L, Bronson, Manzoor A, Wani, Sudhasri, Mohanty   +5 more
openaire   +2 more sources

VIRAL IMMUNE EVASION OF FCRN FUNCTIONS

2018
Human Cytomegalovirus (HCMV) is known to evade host immunity, allowing it to persistently infect humans. Although the strategies of HCMV to evade cellular immunity is well studied, there is limited understanding on how HCMV antagonizes humoral immunity. The neonatal Fc receptor (FcRn), an MHC class I-related FcγR, plays a critical role in IgG-mediated
openaire   +2 more sources