Results 201 to 210 of about 8,114 (214)

FcRn-Targeted Mucosal Vaccination against Influenza Virus Infection

The Journal of Immunology, 2021
Abstract The respiratory tract is constantly exposed to various airborne pathogens. Most vaccines against respiratory infections are designed for the parenteral routes of administration; consequently, they provide relatively minimal protection in the respiratory tract.
Susan Park Ochsner, Weizhong Li, Arunraj Mekhemadhom Rajendrakumar, Senthilkumar Palaniyandi, Gyanada Acharya, Xiaoyang Liu, Gefei Wang, Florian Krammer, Meiqing Shi, Wenbin Tuo, C David Pauza, Xiaoping Zhu   +11 more
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Clinical chemistry of human FcRn transgenic mice

Mammalian Genome, 2011
Mice genetically engineered to express human FcRn are valuable models for the evaluation of therapeutic antibodies in the context of human FcRn in vivo. However, only limited clinical chemistry information on these mouse strains is available. Thus, we have compared 30 clinical chemical parameters of C57BL/6J wild-type mice, murine FcRn-knockout mice ...
Stein, Carsten, Kling, Lothar, Proetzel, Gabriele, Roopenian, Derry C, de Angelis, Martin HrabÄ›, Wolf, Eckhard, Rathkolb, Birgit   +6 more
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FcRn Inhibitor Therapies in Neurologic Diseases

CNS Drugs
In the last decade, the landscape of treating autoimmune diseases has evolved with the emergence and approval of novel targeted therapies. Several new biological agents offer selective and target-specific immunotherapy and therefore fewer side effects, such as neonatal Fc receptor (FcRn)-targeting therapy.
Nouf Alfaidi, Salama Karmastaji, Alexandria Matic, Vera Bril   +3 more
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Multiple roles of FcRn

1998
FcRn is named for the source from which it was first purified, the intestinal epithelium of neonatal rats. Long before the receptor was characterized it was known that rats and mice acquire maternal antibodies by suckling [reviewed in Reference 1].
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FcRn: the neonatal Fc receptor comes of age

Nature Reviews Immunology, 2007
The neonatal Fc receptor for IgG (FcRn) has been well characterized in the transfer of passive humoral immunity from a mother to her fetus. In addition, throughout life, FcRn protects IgG from degradation, thereby explaining the long half-life of this class of antibody in the serum. In recent years, it has become clear that FcRn is expressed in various
Roopenian, D C, Akilesh, S
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Effect of Individual Fc Methionine Oxidation on FcRn Binding: Met252 Oxidation Impairs FcRn Binding More Profoundly than Met428 Oxidation

Journal of Pharmaceutical Sciences, 2015
The long serum half-lives of mAbs are conferred by pH-dependent binding of IgG-Fc to the neonatal Fc receptor (FcRn). The Fc region of human IgG1 has three conserved methionine residues, Met252, Met358, and Met428. Recent studies showed oxidation of these Met residues impairs FcRn binding and consequently affects pharmacokinetics of therapeutic ...
Xuan, Gao, Junyan A, Ji, Karthik, Veeravalli, Y John, Wang, Taylor, Zhang, William, Mcgreevy, Kai, Zheng, Robert F, Kelley, Michael W, Laird, Jun, Liu, Mary, Cromwell   +10 more
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Application of FcRn Binding Assays to Guide mAb Development

Drug Metabolism and Disposition, 2014
Monoclonal antibodies (mAbs) represent an important class of therapeutic modalities. To optimize their pharmaceutical properties, studies have focused on improving mAb pharmacokinetic/pharmacodynamic profiles by modulating their interactions with the neonatal Fc receptor (FcRn).
Amita, Datta-Mannan, Victor J, Wroblewski   +1 more
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Perspective – FcRn transports albumin: relevance to immunology and medicine

Trends in Immunology, 2006
Recent evidence validates a forgotten 40-year-old hypothesis: the MHC-related Fc receptor for IgG (FcRn) protects albumin from intracellular catabolic degradation, as it does for IgG, accounting for the uniquely long half-lives of both molecules and explaining their direct concentration-catabolism relationships.
Clark L, Anderson, Chaity, Chaudhury, Jonghan, Kim, C L, Bronson, Manzoor A, Wani, Sudhasri, Mohanty   +5 more
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VIRAL IMMUNE EVASION OF FCRN FUNCTIONS

2018
Human Cytomegalovirus (HCMV) is known to evade host immunity, allowing it to persistently infect humans. Although the strategies of HCMV to evade cellular immunity is well studied, there is limited understanding on how HCMV antagonizes humoral immunity. The neonatal Fc receptor (FcRn), an MHC class I-related FcγR, plays a critical role in IgG-mediated
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The structure and evolution of FcRn

Research in Immunology, 1996
N E, Simister, J C, Ahouse
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