Results 231 to 240 of about 15,564 (249)

Impact of afucosylation strategy on antibody function: a comparative study of glycoengineered anti-CD20 antibodies Obinutuzumab and Obinutuzumab beta. [PDF]

MAbs
Shuang Q, Sun M, Lin G, Zhang L, Huang S, Shen Q, Jiang L, Yang L, Sun J, Chen H, Li F, Li J.   +11 more
europepmc   +1 more source

Real-world use of efgartigimod in acetylcholine receptor antibody-positive generalized myasthenia gravis: experience from two centers in Greece and Cyprus. [PDF]

Front Neurol
Tsokkos T, Strataki E, Tzavella D, Zamba-Papanicolaou E, Kleopa KA, Zouvelou V.   +5 more
europepmc   +1 more source

Engineering of the albumin-FcRn interaction

, 2017
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Albumin Binding to FcRn:  Distinct from the FcRn−IgG Interaction

Biochemistry, 2006
The MHC-related Fc receptor for IgG (FcRn) protects albumin and IgG from degradation by binding both proteins with high affinity at low pH in the acid endosome and diverting both from a lysosomal pathway, returning them to the extracellular compartment.
Chaity, Chaudhury, Charles L, Brooks, Daniel C, Carter, John M, Robinson, Clark L, Anderson   +4 more
openaire   +2 more sources

FcRn-Targeted Mucosal Vaccination against Influenza Virus Infection

The Journal of Immunology, 2021
Abstract The respiratory tract is constantly exposed to various airborne pathogens. Most vaccines against respiratory infections are designed for the parenteral routes of administration; consequently, they provide relatively minimal protection in the respiratory tract.
Susan Park Ochsner, Weizhong Li, Arunraj Mekhemadhom Rajendrakumar, Senthilkumar Palaniyandi, Gyanada Acharya, Xiaoyang Liu, Gefei Wang, Florian Krammer, Meiqing Shi, Wenbin Tuo, C David Pauza, Xiaoping Zhu   +11 more
openaire   +2 more sources

Clinical chemistry of human FcRn transgenic mice

Mammalian Genome, 2011
Mice genetically engineered to express human FcRn are valuable models for the evaluation of therapeutic antibodies in the context of human FcRn in vivo. However, only limited clinical chemistry information on these mouse strains is available. Thus, we have compared 30 clinical chemical parameters of C57BL/6J wild-type mice, murine FcRn-knockout mice ...
Stein, Carsten, Kling, Lothar, Proetzel, Gabriele, Roopenian, Derry C, de Angelis, Martin HrabÄ›, Wolf, Eckhard, Rathkolb, Birgit   +6 more
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FcRn Inhibitor Therapies in Neurologic Diseases

CNS Drugs
In the last decade, the landscape of treating autoimmune diseases has evolved with the emergence and approval of novel targeted therapies. Several new biological agents offer selective and target-specific immunotherapy and therefore fewer side effects, such as neonatal Fc receptor (FcRn)-targeting therapy.
Nouf Alfaidi, Salama Karmastaji, Alexandria Matic, Vera Bril   +3 more
openaire   +2 more sources

Multiple roles of FcRn

1998
FcRn is named for the source from which it was first purified, the intestinal epithelium of neonatal rats. Long before the receptor was characterized it was known that rats and mice acquire maternal antibodies by suckling [reviewed in Reference 1].
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FcRn: the neonatal Fc receptor comes of age

Nature Reviews Immunology, 2007
The neonatal Fc receptor for IgG (FcRn) has been well characterized in the transfer of passive humoral immunity from a mother to her fetus. In addition, throughout life, FcRn protects IgG from degradation, thereby explaining the long half-life of this class of antibody in the serum. In recent years, it has become clear that FcRn is expressed in various
Roopenian, D C, Akilesh, S
openaire   +2 more sources