Results 241 to 249 of about 15,564 (249)

Effect of Individual Fc Methionine Oxidation on FcRn Binding: Met252 Oxidation Impairs FcRn Binding More Profoundly than Met428 Oxidation

Journal of Pharmaceutical Sciences, 2015
The long serum half-lives of mAbs are conferred by pH-dependent binding of IgG-Fc to the neonatal Fc receptor (FcRn). The Fc region of human IgG1 has three conserved methionine residues, Met252, Met358, and Met428. Recent studies showed oxidation of these Met residues impairs FcRn binding and consequently affects pharmacokinetics of therapeutic ...
Xuan, Gao, Junyan A, Ji, Karthik, Veeravalli, Y John, Wang, Taylor, Zhang, William, Mcgreevy, Kai, Zheng, Robert F, Kelley, Michael W, Laird, Jun, Liu, Mary, Cromwell   +10 more
openaire   +2 more sources

Application of FcRn Binding Assays to Guide mAb Development

Drug Metabolism and Disposition, 2014
Monoclonal antibodies (mAbs) represent an important class of therapeutic modalities. To optimize their pharmaceutical properties, studies have focused on improving mAb pharmacokinetic/pharmacodynamic profiles by modulating their interactions with the neonatal Fc receptor (FcRn).
Amita, Datta-Mannan, Victor J, Wroblewski   +1 more
openaire   +2 more sources

Perspective – FcRn transports albumin: relevance to immunology and medicine

Trends in Immunology, 2006
Recent evidence validates a forgotten 40-year-old hypothesis: the MHC-related Fc receptor for IgG (FcRn) protects albumin from intracellular catabolic degradation, as it does for IgG, accounting for the uniquely long half-lives of both molecules and explaining their direct concentration-catabolism relationships.
Clark L, Anderson, Chaity, Chaudhury, Jonghan, Kim, C L, Bronson, Manzoor A, Wani, Sudhasri, Mohanty   +5 more
openaire   +2 more sources

VIRAL IMMUNE EVASION OF FCRN FUNCTIONS

2018
Human Cytomegalovirus (HCMV) is known to evade host immunity, allowing it to persistently infect humans. Although the strategies of HCMV to evade cellular immunity is well studied, there is limited understanding on how HCMV antagonizes humoral immunity. The neonatal Fc receptor (FcRn), an MHC class I-related FcγR, plays a critical role in IgG-mediated
openaire   +2 more sources

The structure and evolution of FcRn

Research in Immunology, 1996
N E, Simister, J C, Ahouse
openaire   +2 more sources

FcRn

2008
openaire   +1 more source

Tu1660 FcRn Binding and FcRn Mediated Transcytosis by Certolizumab Pegol in Comparison With Other Anti-TNFs

Gastroenterology, 2013
Terry S. Baker, Lara Kevorkian, Andrew Nesbitt   +2 more
openaire   +1 more source

FcRn-Antagonist bei generalisierter Myasthenia gravis

InFo Neurologie + Psychiatrie
Heinz Wiendl, Christian W. Keller
openaire   +1 more source

FcRn and Myasthenia Gravis

openaire   +1 more source