Results 61 to 70 of about 15,564 (249)
Targeting FcRn for the modulation of antibody dynamics [PDF]
Molecular Immunology, 2015 The MHC class I-related receptor, FcRn, is a multitasking protein that transports its IgG ligand within and across cells of diverse origins. The role of this receptor as a global regulator of IgG homeostasis and transport, combined with knowledge of the molecular details of FcRn-IgG interactions, has led to opportunities to modulate the in vivo ...
E Sally, Ward +2 more
openaire +2 more sources
Human FcRn Tissue Expression Profile and Half-Life in PBMCs
Biomolecules, 2019 System-wide quantitative characterization of human neonatal Fc receptor (FcRn) properties is critical for understanding and predicting human PK (pharmacokinetics) as well as the distribution of mAbs and Fc-fusion proteins using PBPK (physiologically ...
Yao-Yun Fan +5 more
doaj +1 more source
FcRn-mediated antibody transport across epithelial cells revealed by electron tomography [PDF]
, 2008 The neonatal Fc receptor (FcRn) transports maternal IgG across epithelial barriers, thereby providing the fetus or newborn with humoral immunity before its immune system is fully functional.
AH Huber +36 more
core +1 more source
Arthritis Care &Research, EarlyView.People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley +1 more source
Advanced Healthcare Materials, EarlyView.The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan +13 more
wiley +1 more source
Frontiers in Immunology, 2015 Despite the reasonably long half-life of IgGs, market pressure for higher patient convenience while conserving efficacy continues to drive IgG half-life improvement.
Céline eMonnet +8 more
doaj +1 more source
Deep Architectures and Ensembles for Semantic Video Classification [PDF]
, 2018 This work addresses the problem of accurate semantic labelling of short videos. To this end, a multitude of different deep nets, ranging from traditional recurrent neural networks (LSTM, GRU), temporal agnostic networks (FV,VLAD,BoW), fully connected ...
Bober, Miroslaw +3 more
core +1 more source
Loss Max-Pooling for Semantic Image Segmentation
, 2017 We introduce a novel loss max-pooling concept for handling imbalanced training data distributions, applicable as alternative loss layer in the context of deep neural networks for semantic image segmentation. Most real-world semantic segmentation datasets
Bulò, Samuel Rota +2 more
core +1 more source
The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells [PDF]
, 2013 The mechanisms by which human immunodeficiency virus type 1 (HIV-1) crosses mucosal surfaces to establish infection are unknown. Acidic genital secretions of HIV-1-infected women contain HIV-1 likely coated by antibody.
Anderson, Deborah J +19 more
core +5 more sources
Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management
Advanced Science, EarlyView.ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak +9 more
wiley +1 more source