Results 81 to 90 of about 7,364 (140)

Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor [PDF]

, 2012
Albumin is the most abundant protein in blood where it has a pivotal role as a transporter of fatty acids and drugs. Like IgG, albumin has long serum half-life, protected from degradation by pH-dependent recycling mediated by interaction with the ...
AP West Jr., AR Mezo, C Chaudhury, C Chaudhury, CJ Finnis, CL Anderson, D Sleep, DC Roopenian, DC Roopenian, DM Woodcock, DP McGregor, ES Ward, G Bohm, G Stehle, HP Montoyo, J Zalevsky, JR Simard, JT Andersen, JT Andersen, JT Andersen, JT Andersen, JT Andersen, JT Andersen, L Evans, L Minchiotti, M Werle, MA Wani, P Prabhat, R Chen, RJ Ober, RJ Ober, RJ Peach, S Curry, S Sugio, SA Chinery, T Payne, T Peters Jr., TT Kuo, V Kenanova, V Kenanova, VE Kenanova, WP Burmeister, WP Burmeister, WP Sheffield   +43 more
core   +2 more sources

Engineering FcRn binding kinetics dramatically extends antibody serum half-life and enhances therapeutic potential

Journal of Biological Engineering
Background Optimizing the IgG Fc domain for neonatal Fc receptor (FcRn) binding is crucial for enhancing antibody pharmacokinetics. The prolonged serum half-life of IgG antibody is governed by its pH-dependent interaction with FcRn, enabling efficient ...
Sanghwan Ko, Migyeong Jo, Munsu Kyung, Wonju Lee, Woo Hyung Ko, Jung-Hyun Na, Youn Seo Chun, Byoung Joon Ko, Sang Taek Jung   +8 more
doaj   +1 more source

Differential trafficking of albumin and IgG facilitated by the neonatal Fc receptor in podocytes in vitro and in vivo.

PLoS ONE, 2019
Proteinuria is strongly associated with kidney disease progression but the mechanisms underlying podocyte handling of serum proteins such as albumin and IgG remain to be elucidated.
James Dylewski, Evgenia Dobrinskikh, Linda Lewis, Pantipa Tonsawan, Makoto Miyazaki, Parmjit S Jat, Judith Blaine   +6 more
doaj   +1 more source

Binding of therapeutic Fc-fused factor VIII to the neonatal Fc receptor at neutral pH associates with poor half-life extension

Haematologica
Fusion of therapeutic proteins to the Fc fragment of human IgG1 promotes their FcRn-mediated recycling and subsequent extension in circulating half-life.
Alejandra Reyes-Ruiz, Sandrine Delignat, Aishwarya Sudam Bhale, Victoria Daventure, Robin V. Lacombe, Leslie Dourthe, Olivier Christophe, Sune Justesen, Krishnan Venkataraman, Jordan D. Dimitrov, Sebastien Lacroix-Desmazes   +10 more
doaj   +1 more source

Skin Lesion Analysis Towards Melanoma Detection Using Deep Learning Network [PDF]

arXiv, 2017
Skin lesion is a severe disease in world-wide extent. Early detection of melanoma in dermoscopy images significantly increases the survival rate. However, the accurate recognition of melanoma is extremely challenging due to the following reasons, e.g.
arxiv  

A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data

CPT: Pharmacometrics & Systems Pharmacology, 2019
Monoclonal antibody (mAb) pharmacokinetics (PK) have largely been predicted via allometric scaling with little consideration for cross‐species differences in neonatal Fc receptor (FcRn) affinity or clearance/distribution mechanisms.
Hannah M. Jones, Zhiwei Zhang, Paul Jasper, Haobin Luo, Lindsay B. Avery, Lindsay E. King, Hendrik Neubert, Hugh A. Barton, Alison M. Betts, Robert Webster   +9 more
doaj   +1 more source

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor [PDF]

, 2016
A large body of data exists demonstrating the key role of FcRn in extending the half-life of therapeutic antibodies by rescuing them from lysosomal degradation.
Piche-Nicholas, Nicole Melissa
core   +1 more source

Effects of mutations in potential phosphorylation sites on transcytosis of FcRn [PDF]

, 2001
Kevin M. McCarthy, Michael Lam, Laura Subramanian, Reena Shakya, Zhenping Wu, Estelle E. Newton, Neil E. Simister   +6 more
openalex   +1 more source

FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines

npj Vaccines
Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies (mAb) to target antigen to specific DC subsets.
Christophe Macri, Matthew Paxman, Devi Jenika, Xiao Peng Lin, Zahra Elahi, Paul A. Gleeson, Irina Caminschi, Mireille H. Lahoud, Jose A. Villadangos, Justine D. Mintern   +9 more
doaj   +1 more source

β2-microglobulin is important for cell surface expression and pH-dependent IgG binding of human FcRn [PDF]

, 2002
Asja Praetor, Walter Hunziker
openalex   +1 more source