Results 51 to 60 of about 370,911 (247)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Structural Integrity Assessment of a Long-Range Artillery Projectile Body via Analytical and Numerical Approaches [PDF]

Journal of Applied and Computational Mechanics
Long-range artillery projectiles can feature a hybrid design that integrates a base bleed unit and a solid rocket motor, offering substantial improvements in ballistic performance. These improvements are accompanied by significant increases in the launch
Abdellah Ferfouri, Damir Jerkovic, Sasa Zivkovic, Toufik Allouche, Nebojsa Hristov   +4 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A Hybrid FE/Spectral Analysis of Turbofan Aeroacoustics

, 2006
This paper has introduced a new method for the analysis of the tonal noise radiated from non-axisymmetric turbofan inlets. It combines a standard FE discretisation of the acoustic field in the axial and radial coordinates with a Fourier spectral representation in the circumferential direction.
Duta, M, Giles, M, Laird, A
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Steel-Concrete Viaducts in the Orastie-Sibiu Highway: a Eurocode Compliant Project

Romanian Journal of Transport Infrastructure, 2013
This paper is intended to show the design of two composite bridges along the Orastie- Sibiu motorway, from the basic concepts, applied without the need for a clause-by- clause checking of codes and standards, to the construction methods.
Giordano Aldo, Răcănel Ionuţ Radu, Voiro Giovanni   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Investigation on adaptability of carbon fiber tube for serial manipulator [PDF]

FME Transactions, 2019
This work describes the investigation on adapting the carbon fiber tube for building lightweight serial manipulator links. The carbon fiber is chosen based on its significant properties such as lightweight and superior mechanical strength, as an ...
Kartikejan P., Sabarianand D.V., Sugantan S.   +2 more
doaj  

Novel Approach to Automated Flow Titration for the Determination of Fe(III)

Molecules, 2020
A novel approach to automated flow titration with spectrophotometric detection for the determination of Fe(III) is presented. The approach is based on the possibility of strict and simultaneous control of the flow rates of sample and titrant streams over
Joanna Kozak, Justyna Paluch, Marek Kozak, Marta Duracz, Marcin Wieczorek, Paweł Kościelniak   +5 more
doaj   +1 more source