Results 71 to 80 of about 2,193,375 (255)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Metallicity measurements using atomic lines in M and K dwarf stars

, 2004
We report the first survey of chemical abundances in M and K dwarf stars using atomic absorption lines in high resolution spectra. We have measured Fe and Ti abundances in 35 M and K dwarf stars using equivalent widths measured from (lambda / Delta ...
Allard, Audouze, Cutri, ESA, Fulbright, George Wallerstein, Gizis, Gratton, Harrington, Hauschildt, Hawley, Jones, Jones, Kupka, Kurucz, Kurucz, Lee, Leggett, Lodders, Luyten, Mermilliod, Mould, Ramírez, Reid, Savanov, Ségransan, Ségransan, van Altena, van den Bergh, Vincent M. Woolf, Viti, Wallerstein, Woolf   +32 more
core   +2 more sources

Iron and zinc grain density in common wheat grown in Central Asia [PDF]

, 2007
Sixty-six spring and winter common wheat genotypes from Central Asian breeding programs were evaluated for grain concentrations of iron (Fe) and zinc (Zn). Iron showed large variation among genotypes, ranging from 25 mg kg1 to 56 mg kg1 (mean 38 mg kg1).
Abugalieva, Aigul, Cakmak, Ismail, Dzhunusova, Mira, Gómez-Becerra, Hugo Ferney, Morgounov, Alexei, Muminjanov, Hafiz, Ozturk, Levent, Yessimbekova, M., Zelenskiy, Yu, Çakmak, İsmail, Öztürk, Levent   +10 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Chemical Compositions of Kinematically Selected Outer Halo Stars

, 2009
Chemical abundances of 26 metal-poor dwarfs and giants are determined from high-resolution and high signal-to-noise ratio spectra obtained with Subaru/HDS. The sample is selected so that most of the objects have outer-halo kinematics.
Alonso, Aoki, Aoki, Baumüller, Beers, Biémont, Booth, Bullock, Busso, Carney, Carretta, Castelli, Castelli, Cayrel, Chiba, Cohen, Frebel, Fulbright, Fulbright, Gang Zhao, Gratton, Heger, Honda, Johnston, Kobayashi, Kurucz, Lai, Lan Zhang, Latham, Masashi Chiba, McWilliam, Miho Ishigaki, Noguchi, Perryman, Ramirez, Reoderer, Ryan, Schlegel, Shetrone, Shetrone, Shigeyama, Sobeck., Sommer-Larsen, Stephens, Stephens, Tsujimoto, Umeda, Wako Aoki, Zhao, Zhao   +49 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

High resolution spectroscopic analysis of seven giants in the bulge globular cluster NGC 6723 [PDF]

, 2016
Globular clusters associated with the Galactic bulge are important tracers of stellar populations in the inner Galaxy. High resolution analysis of stars in these clusters allows us to characterize them in terms of kinematics, metallicity, and individual ...
Grado, A., Limatola, L., Marconi, M., Musella, I., Ripepi, V., Rojas-Arriagada, A., Vásquez, S., Zoccali, M.   +7 more
core   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Influence of skew and cross-coupling on flux-weakening performance of permanent-magnet brushless AC machines [PDF]

, 2009
A method is proposed for predicting the flux-weakening performance of permanent-magnet (PM) brushless ac machines accounting for skew and d-q axis cross-coupling.
Chen, J.T., Gu, C.L., Howe, D., Qi, G., Zhou, L.B., Zhu, Z.Q.   +5 more
core   +1 more source