Results 51 to 60 of about 204,542 (311)

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Estudos das interações dos íons Fe(III) com ácido cafeico na presença de ácido húmico [PDF]

open access: yes, 2010
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Curso de Química.A biodisponibilidade e o transporte de íons metálicos no solo para as plantas são fortemente influenciados pela presença de ligantes ...
Hinkel, Julio Bargen
core  

Electron transfer from humic substances to biogenic and abiogenic Fe(III) oxyhydroxide minerals

open access: yes, 2014
Microbial humic substance (HS) reduction and subsequent abiotic electron transfer from reduced HS to poorly soluble Fe(III) (oxyhydr)oxides, a process named electron shuttling, significantly increases microbial Fe(III) mineral reduction rates.
Piepenbrock, Annette   +2 more
core   +1 more source

Urea Gel Electrophoresis in Studies of Conformational Changes of Transferrin on Binding and Transport of Non-Ferric Metal Ions

open access: yesGels, 2021
Transferrin (Tf) is a crucial transporter protein for Fe(III), but its biological role in binding other metal ions and their delivery into cells remain highly controversial.
Aviva Levina, Boer Wang, Peter A. Lay
doaj   +1 more source

Mitochondria have Fe(III) receptors [PDF]

open access: yesBiochemical Journal, 1990
Recent work has provided new evidence that ATP is the major constituent of the low-Mr iron pool in the reticulocyte. The interaction of the iron complex of ATP with mitochondria was investigated in the present experiments. When ATP-Fe3+ was incubated with mitochondria, Fe3+, free of ATP, bound with high affinity to Fe3+ receptors on the mitochondria ...
J, Weaver, H, Zhan, S, Pollack
openaire   +2 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Low-cost biosorption of Fe(II) and Fe(III) from single and binary solutions using Ulva lactuca-derived cellulose nanocrystals-graphene oxide composite film

open access: yesScientific Reports, 2023
The marine algal biomass of Ulva lactuca was utilized for the extraction of cellulose and the development of cellulose nanocrystals/graphene oxide film. Cellulose nanocrystals with 50–150 nm were produced by H2SO4 hydrolysis of the algal cellulose.
Arwa A. Al-Badaani   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

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