Results 61 to 70 of about 204,542 (311)

Drug-coated balloons vs drug-eluting stents for the treatment of large native coronary artery disease. Meta-analysis of randomized controlled trials

REC: Interventional Cardiology (English Ed.)
Introduction and objectives: To compare the effects of drug-coated balloon (DCB) vs drug-eluting stent (DES) in patients presenting with de novo large vessel coronary artery disease (CAD).
José Antonio Sorolla Romero, Laura Novelli, Jorge Llau García, Sara Huélamo Montoro, Pablo Rubio, José Luis Díez Gil, Luis Martínez-Dolz, Ignacio J. Amat Santos, Bernardo Cortese, Fernando Alfonso, Hector M. Garcia-Garcia, Jorge Sanz-Sánchez   +11 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Interpenetrated (8,3)-c and (10,3)-b Metal–Organic Frameworks Based on {Fe III 3 } and {Fe III 2 Co II } Pivalate Spin Clusters

, 2014
MOFs composed of interpenetrated (8,3)-c and (10,3)-b coordination networks based on trinuclear Fe(III) and Fe(III)/Co(II) pivalate clusters and N-donor organic linkers were synthesized and ...
Decurtius, Silvio, Speldrich, M., Van Leusen, J., Speldrich, Manfred, Hermann, Raphael, Kögerler, P., Filippova, Irina G., Kravtsov, V. C., Hauser, J., Decurtins, S., Baca, S. G., Botezat, O., Liu, S.-X., van Leusen, Jan, Krämer, Karl, Filippova, I. G., Kögerler, Paul, Baca, Svetlana G., Botezat, Olga, Liu, Shi-Xia, Hauser, Jürg, Hermann, Raphaël P., Krämer, Karl W., Kravtsov, Victor Ch., Decurtins, Silvio, Krämer, K. W.   +25 more
core   +1 more source

The five-to-six-coordination transition of ferric human serum heme-albumin is allosterically-modulated by ibuprofen and warfarin: a combined XAS and MD study.

PLoS ONE, 2014
Human serum albumin (HSA) is involved physiologically in heme scavenging; in turn, heme-albumin (HSA-heme-Fe) displays globin-like properties. Here, the allosteric effect of ibuprofen and warfarin on the local atomic structure around the ferric heme-Fe ...
Carlo Meneghini, Loris Leboffe, Monica Bionducci, Gabriella Fanali, Massimiliano Meli, Giorgio Colombo, Mauro Fasano, Paolo Ascenzi, Settimio Mobilio   +8 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Influence of Sulfides on Soluble Organic-Fe(III) in Anoxic Sediment Porewaters

, 2002
Solid and colloidal iron oxides are commonly involved in early diagenesis. More readily available soluble Fe(III) should accelerate the cycling of iron (Fe) and sulfur (S) in sediments. Experiments with synthetic solutions (Taillefert et al. 2000) showed
Theberge, Stephen, Taillefert, M., Luther, George W., III, Hover, V. C., Rozan, Tim F.   +4 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Does As(III) interact with Fe(II), Fe(III) and organic matter through ternary complexes?

, 2016
International audienceUp until now, only a small number of studies have been dedicated to the binding processes of As(III) with organic matter (OM) via ionic Fe(III) bridges; none was interested in Fe (II). Complexation isotherms were carried out with As(
Davranche, Mélanie, Bouhnik-Le Coz, Martine, Demangeat, Edwige, Gruau, Gérard, Catrouillet, Charlotte, Dia, Aline   +5 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Coprecipitation thermodynamics of iron(II–III) hydroxysulphate green rust from Fe(II) and Fe(III) salts

, 2003
International audienceIron(II–III) hydroxysulphate GR(SO42−) was prepared by precipitating a mixture of Fe(II) and Fe(III) sulphate solutions with NaOH, accompanied in most cases by iron(II) hydroxide, spinel iron oxide(s) or goethite.
Génin, J.-M.R., Gehin, A., Refait, Ph, Abdelmoula, Mustapha   +3 more
core   +1 more source