Results 171 to 180 of about 553,570 (305)

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, EarlyView.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Biomimetic Copper Nanoparticles Coated with ACE2‐Overexpressing Membranes for Selective SARS‐CoV‐2 Neutralization and Disinfection

Advanced Healthcare Materials, EarlyView.
By fusing ACE2‐overexpressing membrane‐integrated liposome (MIL) with copper nanoparticles, the biomimetic Cu@MIL nanostructures were created that directly hijack the SARS‐CoV‐2 entry pathway. These particles combine potent virus‐targeting precision with intrinsic antiviral activity, achieving rapid neutralization and disinfection.
Pooja Aich, Wei‐Pang Chung, Wen‐Jyun Wang, Hidenobu Takahashi, Ming‐Shun Hsieh, Ying‐Chen Lin, Oh Seok Kwon, Wei‐Peng Li, Wei‐Lun Huang   +8 more
wiley   +1 more source

Soft Neural Interfaces for Circuit‐Level Analysis of Magnetogenetic Deep Brain Stimulation in Parkinson's Disease Models

Advanced Healthcare Materials, EarlyView.
ABSTRACT Magnetogenetic deep brain stimulation (MG‐DBS) represents a wireless neuromodulation that has demonstrated long‐lasting behavioral benefits in Parkinson's disease models. However, the circuit‐level mechanisms underlying these therapeutic effects have remained uncharacterized due to limitations of conventional neural interfaces.
Jakyoung Lee, Yeongdo Lee, Enji Kim, Hunkyu Seo, Myoungjae Oh, Hanho Joo, Somin Lee, Jae‐Hyun Lee, Hyun Ho Jung, Minsuk Kwak, Jang‐Ung Park   +10 more
wiley   +1 more source

Predicting compatibility between ferredoxins and the Fe protein of nitrogenase using in silico protein modeling. [PDF]

Protein Sci
Biswas A, Trachtova K, Fixen KR.
europepmc   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Photothermal‐Activated Antibacterial Amyloid‐Polyphenol‐Iron Hydrogels for Synergistic Wound Healing

Advanced Healthcare Materials, EarlyView.
We report a thermally triggered supramolecular hydrogel (LTFe) formed by Fe3+ and tannic acid on lysozyme amyloid fibrils. Fe3+ enables rapid gelation and photothermal transduction with an efficiency of 88.56%. The LTFe hydrogel exhibits excellent biocompatibility, potent antibacterial activity against E. coli and S.
Di Wu, Jiangtao Zhou, Yang Shen, Qiyao Sun, Tong Li, Xiaoyang Zou, Bin Liu, Hongshan Liang, Raffaele Mezzenga   +8 more
wiley   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Airborne 1O2 Delivery via a Superhydrophobic Dressing as a Pathway to Next‐Generation Wound Therapies, an in Vivo Murine Burn Model Study

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the SH bandage placed on an infected burn wound and its role in wound healing. A superhydrophobic PDMS membrane coated with the PS verteporfin is placed over the wound area and illuminated with a red laser at 690 nm, generating airborne 1O2 above the tissue.
Fernanda Viana Cabral, QianFeng Xu, Natalie Eidenschink, Pareesha Haresh, Alessandra Nara de Souza Rastelli, Jeremy Goverman, Alexander Greer, Alan M. Lyons, Tayyaba Hasan   +8 more
wiley   +1 more source