Results 51 to 60 of about 186,109 (312)
ChemistryOpen, 2022 The outer mitochondrial membrane protein mitoNEET (mNT) is a recently identified iron‐sulfur protein containing a unique Fe2S2(His)1(Cys)3 metal cluster with a single Fe−N(His87) coordinating bond.
Jing‐Yuan Nie +3 more
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Switching on Endogenous Metal Binding Proteins in Parkinson’s Disease
Cells, 2019 The formation of cytotoxic intracellular protein aggregates is a pathological signature of multiple neurodegenerative diseases. The principle aggregating protein in Parkinson’s disease (PD) and atypical Parkinson’s diseases is α ...
Fleur A. McLeary +7 more
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STUDIES ON IRON-PROTEIN METABOLISM WITH RADIOIRON (Fe-55 and Fe-59)
The Japanese Journal of Physiology, 1955 1. In the control group, the turnover rate of hemoglobin radioiron was higher than the appearance of ferritin radioiron in tissues.2. In tne early stage of the acute hemolytic anemia group, the turnover rate of hemoglobin radioiron was higher than the control group and disappearance of hemoglobin radioiron also faster.3.
openaire +3 more sources
Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral [PDF]
Proceedings of the National Academy of Sciences, 2003 Iron is concentrated in ferritin, a spherical protein with a capacious cavity for ferric nanominerals of <4,500 Fe atoms. Global ferritin structure is very stable, resisting 6 M urea and heat (85°C) at neutral pH. Eight pores, each formed by six helices from 3 of the 24 polypeptide subunits, restrict mineral access to reductant,
Xiaofeng, Liu +2 more
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Sulfur Administration in Fe–S Cluster Homeostasis
Antioxidants, 2021 Mitochondria are the key organelles of Fe–S cluster synthesis. They contain the enzyme cysteine desulfurase, a scaffold protein, iron and electron donors, and specific chaperons all required for the formation of Fe–S clusters.
Leszek Rydz +2 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Nucleotide binding by the nitrogenase Fe protein: a 31P NMR study of ADP and ATP interactions with the Fe protein of Klebsiella pneumoniae [PDF]
Biochemical Journal, 1998 Investigation of the interaction of MgADP- and MgATP2- with the Fe protein of Klebsiella pneumoniae nitrogenase by 31P NMR showed that the adenine nucleotides are reversibly bound in slow exchange with free nucleotides. Dissociation of the MgADP-–Fe protein complex was slow enough to enable its isolation by gel filtration, thus permitting the ...
R W, Miller +4 more
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Reciprocal allosteric modulation of carbon monoxide and warfarin binding to ferrous human serum heme-albumin. [PDF]
PLoS ONE, 2013 Human serum albumin (HSA), the most abundant protein in human plasma, could be considered as a prototypic monomeric allosteric protein, since the ligand-dependent conformational adaptability of HSA spreads beyond the immediate proximity of the binding ...
Alessio Bocedi +10 more
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Antioxidants, 2021 Glutaredoxins (GRXs) are thioredoxin superfamily members exhibiting thiol-disulfide oxidoreductase activity and/or iron-sulfur (Fe-S) cluster binding capacities. These properties are determined by specific structural factors.
Thomas Roret +9 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source