Results 71 to 80 of about 553,570 (305)

Concentration-dependent effect of norfloxacin on iron toxicity in the intestine of large yellow croaker Larimichthys crocea (Richardson, 1846)

open access: yesFrontiers in Marine Science
This study explores the effects of norfloxacin (NOR) on oxidative damage, iron (Fe) transport, energy metabolism, and immunotoxicity in the intestine of large yellow croaker under Fe stress.
Lin Zeng   +7 more
doaj   +1 more source

Mapping the Cytochrome C Folding Landscape [PDF]

open access: yes, 2003
The solution to the riddle of how a protein folds is encoded in the conformational energy landscape for the constituent polypeptide. Employing fluorescence energy transfer kinetics, we have mapped the S.
Lyubovitsky, Julia Gennadievna
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Rat liver antioxidant response to iron and copper overloads [PDF]

open access: yes, 2014
The rat liver antioxidant response to Fe and Cu overloads (0–60 mg/kg) was studied. Dose- and time-responses were determined and summarized by t1/2 and C50, the time and the liver metal content for half maximal oxidative responses.
Boveris, Alberto Antonio   +8 more
core   +1 more source

Association of Mitochondrial Function and Feed Efficiency

open access: yesThe Journal of Poultry Science, 2007
Studies were conducted to evaluate the potential link between mitochondrial function and biochemistry with the phenotypic expression of feed efficiency (FE) in a single line of broilers fed the same diet.
Carolyn P. Ojano-Dirain   +3 more
doaj   +1 more source

An essential role for an Fe-S cluster protein in the cytochrome c oxidase complex of Toxoplasma parasites.

open access: yesPLoS Pathogens, 2023
The mitochondrial electron transport chain (ETC) of apicomplexan parasites differs considerably from the ETC of the animals that these parasites infect, and is the target of numerous anti-parasitic drugs.
Rachel A Leonard   +4 more
doaj   +1 more source

Spectroscopic Studies on \u3cem\u3eArabidopsis\u3c/em\u3e ETHE1, a Glyoxalase II-like Protein [PDF]

open access: yes, 2008
ETHE1 (ethylmalonic encephalopathy protein 1) is a β-lactamase fold-containing protein that is essential for the survival of a range of organisms. In spite of the apparent importance of this enzyme, very little is known about its function or biochemical ...
Bennett, Brian   +3 more
core   +1 more source

Potential of proteins and their expression level in marine phytoplankton (Prymnesium parvum) as biomarker of N, P and Fe conditions in aquatic systems [PDF]

open access: yes, 2013
Nitrogen (N), phosphorus (P) and Iron (Fe) are im-portant nutrients for phytoplankton, and are key limiting nutrients in many marine systems. In the present study, growth and protein expression of ma-rine phytoplankton Prymnesium parvum under dif-ferent ...
Hasegawa, H   +4 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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