Results 91 to 100 of about 553,570 (305)

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Differential Diel Translation of Transcripts With Roles in the Transfer and Utilization of Iron-Sulfur Clusters in Arabidopsis

Frontiers in Plant Science, 2018
Iron-sulfur (Fe-S) clusters are evolutionarily ancient ubiquitous protein cofactors which have mostly catalytic functions but can also have structural roles.
Hongliang Zhang, Ute Krämer
doaj   +1 more source

Mitochondria function in cytoplasmic FeS protein biogenesis

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Iron‑sulfur (FeS) clusters are cofactors of numerous proteins involved in essential cellular functions including respiration, protein translation, DNA synthesis and repair, ribosome maturation, anti-viral responses, and isopropylmalate isomerase activity.
Andrew, Dancis, Ashutosh K, Pandey, Debkumar, Pain   +2 more
openaire   +2 more sources

Activation of STAT3 by the c-Fes Protein-tyrosine Kinase [PDF]

Journal of Biological Chemistry, 1998
STATs (signal transducers and activators of transcription) are transcription factors that contain SH2 domains and are activated by tyrosine phosphorylation, often in response to cytokine stimulation. Recent evidence indicates that the transforming tyrosine kinases encoded by the v-Src, v-Abl, and v-Fps oncogenes can induce STAT activation, suggesting ...
K L, Nelson, J A, Rogers, T L, Bowman, R, Jove, T E, Smithgall   +4 more
openaire   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Bacterial-type oxygen detoxification and iron-sulfur cluster assembly in amoebal relict mitochondria. [PDF]

, 2013
addresses: School of Biological Sciences, Royal Holloway University of London, Egham TW20 0EX, UK.types: Journal Article; Research Support, Non-U.S. Gov'tOnline open article.
Aguilera, Ali, Arias, Bakatselou, Bakatselou, Beinert, Beinert, Bradford, Chan, Choi, Clark, Coulter, Coulter, Craig, Davis, Diamond, Dolezal, Embley, Embley, Embley, Esser, Frazzon, Gerber, Ghosh, Gill, Goldberg, Jin, Katinka, Kurland, León-Avila, Lill, Lill, Loftus, Loiseau, Lucattini, Mahendrasingam, Morrison, Müller, Müller, Outten, Pütz, Rees, Reeves, Regoes, Stanley, Suták, Takahashi, Tovar, Tovar, Tovar, van der Giezen, van der Giezen, van der Giezen, Vicente, Weinberg   +54 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Direct Involvement of ombB, omaB and omcB Genes in Extracellular Reduction of Fe(III) by Geobacter sulfurreducens PCA

Frontiers in Microbiology, 2015
The tandem gene clusters orfR-ombB-omaB-omcB and orfS-ombC-omaC-omcC of the metal-reducing bacterium Geobacter sulfurreducens PCA are responsible for trans-outer membrane electron transfer during extracellular reduction of Fe(III)-citrate and ...
Yimo eLiu, Jim K Fredrickson, John M Zachara, Liang eShi   +3 more
doaj   +1 more source