Results 71 to 80 of about 480,216 (163)

Electrocortical and Physiological Correlates of Memory and Attention During the Anticipation of Avoidable and Inevitable Threats

Psychophysiology, Volume 63, Issue 10, October 2026.
ABSTRACT When confronted with danger, humans display a range of defensive behaviors, such as freezing and active avoidance. Prior research has identified a distinct physiological response pattern to avoidable threats, characterized by heart rate bradycardia, reduced visual exploration, and suppressed visual alpha activity (8–13 Hz), all of which are ...
Yannik Stegmann, Matthias Gamer
wiley   +1 more source

The effects of spaced versus massed extinction training on extinction retention of conditioned fear learning in male rats

Frontiers in Behavioral Neuroscience
IntroductionExtinction learning of conditioned fear behavior has been used as a translational model to study human fear-, anxiety-, trauma-, and stressor-related disorders and their underlying neurobiology in animal models because the underlying neural ...
Grant W. LeVasseur, Timothy Cilley, Michelle Szewczuk, Shane A. Perrine, Seth D. Norrholm   +4 more
doaj   +1 more source

BDNF-dependent consolidation of fear memories in the perirhinal cortex

Frontiers in Behavioral Neuroscience, 2013
In the recent years the perirhinal cortex (PRh) has been identified as a crucial brain area in fear learning. Since the neurotrophin BDNF (brain-derived neurotrophic factor) is an important mediator of synaptic plasticity and also crucially involved in ...
Brigitte eSchulz-Klaus, Volkmar eLessmann, Thomas eEndres   +2 more
doaj   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, Volume 13, Issue 50, 7 September 2026.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Olfactory bulbectomy does not affect conditioned inhibition of fear as measured with fear-potentiated startle

, 1999
The present study examined the effects of olfactory bulbectomy, an animal model of depression, on conditioned inhibition as measured with fear-potentiated startle, an animal model of anxiety.
Leal-Puente, Laura
core   +1 more source

Impaired Synaptic Plasticity in a Rodent Model of Intimate Partner Violence‐Related Brain Injury

Hippocampus, Volume 36, Issue 5, September 2026.
ABSTRACT Intimate partner violence‐related brain injury (IPV‐BI) predominantly affects women and often reflects both structural trauma from mild traumatic brain injury (mTBI), as well as ischemia/hypoxia from non‐fatal strangulation (NFS). This polytrauma can impair cognitive function, particularly learning and memory processes, which may contribute to
Justin Brand, Eric Eyolfson, Kirsten R. B. Suesser, Emma S. J. Smith, Zoe L. Thompson, Stuart J. McDonald, Jodie R. Gawryluk, Sandy R. Shultz, Brian R. Christie   +8 more
wiley   +1 more source

Fear Potentiated Startle and the Effects of Losartan on Extinction Learning

, 2019
Background – PTSD is a chronic and debilitating mental illness with limited available treatments. New medications, including Angiotensin Type 1 Receptor inhibitors, have been found to improve extinction learning retention in rodents and could be a means ...
Seidenberg, Jessica
core   +1 more source

The role of fear learning in the development of psychosis: an EEG study utilizing a differential fear conditioning paradigm in people with psychotic vulnerability

Schizophrenia
By studying how individuals in an “at-risk” state of psychosis learn about threat and safety cues – specifically, how they develop and unlearn fear responses to neutral cues – we might better understand the mechanisms leading to heightened arousal and ...
Metin Özyagcilar, Nilay Esin Ahrens-Demirdal, Anja Riesel, Tina B. Lonsdorf, Tania M. Lincoln   +4 more
doaj   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 196-219, September 2026.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source

No impact of deep brain stimulation on fear-potentiated startle in obsessive-compulsive disorder

Frontiers in Behavioral Neuroscience, 2014
Deep brain stimulation (DBS) of the ventral internal capsule is effective in treating therapy refractory obsessive-compulsive disorder (OCD). Given the close proximity of the stimulation site to the stria terminalis (BNST), we hypothesized that the ...
Johanna M.P. Baas, Johanna M.P. Baas, Floris eKlumpers, Mariska H Mantione, Martijn eFigee, Nienke C Vulink, P. Richard Schuurman, Ali eMazaheri, Damiaan eDenys, Damiaan eDenys   +9 more
doaj   +1 more source