Results 101 to 110 of about 50,736 (309)
Extinction of negative conditioned stimulus valence in human fear conditioning
Fear conditioning is a common experimental paradigm for modelling the development, and exposure-based treatment, of anxiety disorders. Measures of fear such as threat-expectancy, physiological arousal, and fear ratings typically extinguish, however ...
Hyde, J, Waters, AM, Farrell, LJ
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, 2013 Individual variability in the acquisition, consolidation and extinction of conditioned fear potentially contributes to the development of fear pathology including posttraumatic stress disorder (PTSD).
Palmer, Abraham A. +5 more
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ABL1 in thalamus is associated with safety but not fear learning
Frontiers in Systems Neuroscience, 2013 In auditory fear conditioning a tone is paired with a footshock, establishing long lasting fear memory to the tone. In safety learning these stimuli are presented in an unpaired non-overlapping manner and enduring memories to the tone as a safety signal ...
Mouna Rohana Habib +3 more
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Exposure and the reduction of fear of pain [PDF]
, 2012 This research investigated interoceptive exposure as a treatment option for disabling pain-related fear. Interoceptive exposure was conceptualised as an extension of the Fear Avoidance Model and a literature review highlighted three important areas ...
Taylor, Siobhan Catherine
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, 2019 Cue and contextual fear conditioning were improved with AVL-3288 treatment in TBI animals. A) Time course of AVL-3288 treatment (arrows) and behavioral analyses. Animals were serially tested on fear conditioning and then on the water maze tasks.
Coleen M. Atkins (4037060) +7 more
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Fear-learning is altered in a mouse neuropathic pain model
Frontiers in Pain ResearchBackgroundWhile chronic neuropathic pain is characterised by abnormal pain signs, such as allodynia, highly disabling co-morbidities, such as anxiety and depression, have a major impact.
Neda Assareh +9 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
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Fear, whether innate or learned, is an essential emotion required for survival. The learning, and subsequent memory, of fearful events enhances our ability to recognise and respond to threats, aiding adaptation to new, ever-changing environments ...
Parwana, Krishma +5 more
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Equal pain – Unequal fear response: Enhanced susceptibility of tooth pain to fear conditioning
Frontiers in Human Neuroscience, 2014 Experimental fear conditioning in humans is widely used as a model to investigate the neural basis of fear learning and to unravel the pathogenesis of anxiety disorders. It has been observed that fear conditioning depends on stimulus salience and subject
Michael Lukas Meier +10 more
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