Results 111 to 120 of about 50,736 (309)
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
GABA(B) receptor-mediated modulation of synaptic plasticity in the lateral amygdala [PDF]
, 2005 Fear conditioning, one of the most powerful and widely used methods to investigate the mechanisms of associative learning in animals, involves the pairing of an aversive stimulus such as a foot-shock (the unconditioned stimulus; US) with a neutral ...
Shaban, Hamdy
core +1 more source
Effects of local anesthesia of the cerebellum on classical fear conditioning in goldfish
Behavioral and Brain Functions, 2010 Background Besides the amygdala, of which emotion roles have been intensively studied, the cerebellum has also been demonstrated to play a critical role in simple classical fear conditioning in both mammals and fishes.
Hirano Ruriko, Yoshida Masayuki
doaj +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Mindfulness and fear conditioning
, 2016 During mindfulness-based interventions participants can be invited to bring aversive stimuli to mind while practicing mindfulness. This is thought to help the stimuli become less aversive.
McLaren, R., Jones, F., McLaren, I.
core
Modeling fear‐conditioned bradycardia in humans
Psychophysiology, 2016 AbstractAcross species, cued fear conditioning is a common experimental paradigm to investigate aversive Pavlovian learning. While fear‐conditioned stimuli (CS+) elicit overt behavior in many mammals, this is not the case in humans. Typically, autonomic nervous system activity is used to quantify fear memory in humans, measured by skin conductance ...
Castegnetti Giuseppe +5 more
openaire +7 more sources
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
, 1998 A role for corticosterone in the consolidation of contextual fear conditioning has previously been proposed. In this study, physiological evidence was found to support this view.
Cordero, Isabel +2 more
core +1 more source
Frontiers in Human Neuroscience, 2014 Extinction is an important mechanism to inhibit initially acquired fear responses. There is growing evidence that the ventromedial prefrontal cortex (vmPFC) inhibits the amygdala and therefore plays an important role in the extinction of delay fear ...
Heike eEwald +8 more
doaj +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source