Results 131 to 140 of about 716,992 (304)

S6-4: Visual Awareness Modulated by Conditioned Fear during Bistable Perception

i-Perception, 2012
Bistable perception has been considered as a useful means to study visual awareness since it induces spontaneous fluctuation in awareness despite constant physical stimulation. Whether visual awareness during bistable perception is modulated by emotional
Chai-Youn Kim
doaj   +1 more source

Quantitative proteomics of auditory fear conditioning

, 2013
Auditory fear conditioning is a well-characterized rodent learning model where a neutral auditory cue is paired with an aversive outcome to induce associative fear memory. The storage of long-term auditory fear memory requires long-term potentiation (LTP)
Park, Sungmo, Yun, Ki Na, Park, Young Mok, Lee, Sukvvon, Kang, Taewook, Yoo, YongCheol, Choi, Sukwoo, Kwon, Kyung-Hoon, Song, Sukwoon, Kim, Jihye, Song, Beomjong, Kim, Jeongyeon, Hong, Ingie, Kim, Jin Young, An, Bobae   +14 more
core   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Central Amygdala Activity during Fear Conditioning

, 2011
The central amygdala (Ce), particularly its medial sector (CeM), is the main output station of the amygdala for conditioned fear responses. However, there is uncertainty regarding the nature of CeM control over conditioned fear.
Daniela Popa, Denis Paré, Sevil Duvarci
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Fear learning in unmedicated patients with anxiety disorders: a comparison of delay conditioning, fear reversal, and trace conditioning [PDF]

Anxiety disorders are common and impairing, yet their underlying mechanisms remain incompletely understood. Fear learning provides a critical translational framework for investigating pathological anxiety, bridging laboratory models and clinical ...
Peña Arteaga, Víctor de la, Shackman, Alexander J., Fullana Rivas, Miguel Àngel, Saiz-Masvidal, Cristina, Juaneda-Seguí, Asier, Radua, Joaquim, Battaglia, Simone, Martínez Zalacaín, Ignacio, Soriano Mas, Carles, Vilajosana, Enric, Chavarría-Elizondo, Pamela   +10 more
core   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

O hipocampo e o condicionamento olfatório aversivo: mediação por receptores glutamatérgicos subtipo NMDA [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2012Memórias olfatórias são geralmente associadas a experiências emocionais; portanto, a associação entre ...
Kroon, Juliana Amorim Vieira
core  

Fear conditioning tests.

, 2012
A. The freezing percentage during the acquisition stage of the trace fear conditioning. The freezing percentage increased in all groups during the three trials of the trace fear conditioning, indicating that the mice were learning. B.
Jhe-Wei Shen (190223), Ni-Chun Chung (190225), Ingrid Y. Liu (190231), Ming-Yuan Min (190227), Sin-Jong Cheng (190230), Chien-Chang Chen (190221)   +5 more
core   +1 more source