Results 91 to 100 of about 716,992 (304)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Efeitos do midazolam, propanolol e escopolamina em ratos submetidos ao modelo de condicionamento olfatório do medo [PDF]
, 2007 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Experiências de medo podem estabelecer memórias emocionais que resultam em mudanças comportamentais.
Kroon, Juliana Amorim Vieira
core
, 2019 Cue and contextual fear conditioning were improved with AVL-3288 treatment in TBI animals. A) Time course of AVL-3288 treatment (arrows) and behavioral analyses. Animals were serially tested on fear conditioning and then on the water maze tasks.
Coleen M. Atkins (4037060) +7 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A delay and trace fear conditioning paradigm in humans: time-dependent effects of corticosteroids?
European Journal of Psychotraumatology, 2012 Background : Corticosteroids are released in response to stress and have been shown to influence affective learning in rodents and humans. Many models of pathogenesis of affective and anxiety disorders have incorporated stress and cortisol as ...
Sandra Cornelisse +3 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2017 Astrocytes are well known to scale synaptic structural and functional plasticity, while the role in learning and memory, such as conditioned fear memory, is poorly elucidated.
Zhaohui Liao +6 more
doaj +1 more source
Fear conditioning retention sessions.
, 2013 Mean ± SEM (A) Recent time point. Percentage freezing during the context memory retention session for rats that underwent contextual fear conditioning 1 week prior to HPC surgery. Sham rats froze significantly more than either lesion group.
Hugo Lehmann (339623) +3 more
core +1 more source
Weakening Visual Function Enhances Auditory Fear Conditioning in Mice
, 2021 As advanced cognitive activities, it is poorly understood if visual weakening affects auditory fear conditioning. Here we investigated the responses in auditory Pavlovian fear conditioning, using mutant rd/rd, cl/cl mice as visual weakening group ...
Ma Man-Xiu +6 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
ABL1 in thalamus is associated with safety but not fear learning
Frontiers in Systems Neuroscience, 2013 In auditory fear conditioning a tone is paired with a footshock, establishing long lasting fear memory to the tone. In safety learning these stimuli are presented in an unpaired non-overlapping manner and enduring memories to the tone as a safety signal ...
Mouna Rohana Habib +3 more
doaj +1 more source