Results 71 to 80 of about 50,736 (309)
Comparison of inbred mouse substrains reveals segregation of maladaptive fear phenotypes
Frontiers in Behavioral Neuroscience, 2014 Maladaptive fear, such as fear that is persistent or easily generalized to a nonthreatening stimuli, is associated with anxiety-related disorders in humans. In the laboratory, maladaptive fear can be modeled in rodents using Pavlovian fear conditioning.
Stephanie J Temme +5 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Intraperitoneal 8-OH-DPAT reduces competition from contextual but not discrete conditioning cues
, 2019 The effects of the serotonergic (5-hydroxytryptamine, 5-HT) agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.2 and 0.4 mg/kg i.p.) were examined in trace conditioning (Experiment 1) and overshadowing (Experiment 2) procedures.
Cassaday, H.J., Thur, K.E.
core +1 more source
Fear conditioning and naloxone
, 2023 We will conduct two experiments with rats (male wistar rats, n=8) intended to 1) analyze the effect of naloxone on fear conditioning and 2) the effects of testing fear conditioning in presence of a context repeatedly associated with the effects of ...
Luis Gonzalo de la Casa
core +1 more source
Bilateral Alternating Auditory Stimulations Facilitate Fear Extinction and Retrieval
Frontiers in Psychology, 2017 Disruption of fear conditioning, its extinction and its retrieval are at the core of posttraumatic stress disorder (PTSD). Such deficits, especially fear extinction delay, disappear after alternating bilateral stimulations (BLS) during eye movement ...
Sarah Boukezzi +10 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
An organization of visual and auditory fear conditioning in the lateral amygdala
, 2014 Pavlovian fear conditioning is an evolutionary conserved and extensively studied form of associative learning and memory. In mammals, the lateral amygdala (LA) is an essential locus for Pavlovian fear learning and memory.
Bergstrom, Hadley C., Johnson, Luke R.
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Fear conditioning-related changes in cerebellar Purkinje cell activities in goldfish
Behavioral and Brain Functions, 2012 Background Fear conditioning-induced changes in cerebellar Purkinje cell responses to a conditioned stimulus have been reported in rabbits. It has been suggested that synaptic long-term potentiation and the resulting increases in firing rates of Purkinje
Yoshida Masayuki, Kondo Hiroki
doaj +1 more source
Neurobiology of Pavlovian Fear Conditioning [PDF]
Annual Review of Neuroscience, 2001 ▪ Abstract Learning the relationships between aversive events and the environmental stimuli that predict such events is essential to the survival of organisms throughout the animal kingdom. Pavlovian fear conditioning is an exemplar of this form of learning that is exhibited by both rats and humans.
openaire +2 more sources