Results 61 to 70 of about 50,736 (309)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Efeitos do midazolam, propanolol e escopolamina em ratos submetidos ao modelo de condicionamento olfatório do medo [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Experiências de medo podem estabelecer memórias emocionais que resultam em mudanças comportamentais.
Kroon, Juliana Amorim Vieira
core  

Plasticity of fear and safety neurons of the amygdala in response to fear extinction

Frontiers in Behavioral Neuroscience, 2015
Fear inhibition learning induces plasticity and remodeling of circuits within the amygdala. Most studies examine these changes in nondiscriminative fear conditioning paradigms.
Susan eSangha, Susan eSangha
doaj   +1 more source

Multiverse analyses in fear conditioning research

Behaviour Research and Therapy, 2021
There is heterogeneity in and a lack of consensus on the preferred statistical analyses foranalyzing fear conditioning effects in light of a multitude of potentially equally justifiablestatistical approaches. Here, we introduce the concept of multiverse analysis for fearconditioning research.
Tina B Lonsdorf, Anna Gerlicher, Maren Klingelhöfer-Jens, Angelos-Miltiadis Krypotos   +3 more
openaire   +7 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Efeito do pentilenotetrazol e do midazolam na aquisição e na expressão da resposta defensiva de ratos submetidos ao condicionamento olfatório de medo [PDF]

, 2009
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.O condicionamento Pavloviano de medo ou condicionamento de medo de primeira ordem tem sido amplamente utilizado para
Cavalli, Juliana
core  

Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear

, 2023
Contextual fear conditioning (CFC) is mediated by a neural circuit that includes the hippocampus, prefrontal cortex, and amygdala, but the neurophysiological mechanisms underlying the regulation of CFC by neuromodulators remain unclear.
Tobias Bast, Helen J. Cassaday, Christine Stubbendorff, Stephen J. Martin, Ed Hale, Hale, Ed, Carl W. Stevenson, Martin, Stephen J.; id_orcid, Sopapun Suwansawang, Cassaday, Helen J, Stevenson, Carl W, Stubbendorff, Christine, Martin, Stephen J., Suwansawang, Sopapun, David M. Halliday, Halliday, David M., Halliday, David M, Martin, Stephen J, Bast, Tobias, Stevenson, Carl W., Cassaday, Helen J.   +20 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Repeated elicitation of the acoustic startle reflex leads to sensitisation in subsequent avoidance behaviour and induces fear conditioning [PDF]

, 2011
Background: Autonomous reflexes enable animals to respond quickly to potential threats, prevent injury and mediate fight or flight responses. Intense acoustic stimuli with sudden onsets elicit a startle reflex while stimuli of similar intensity but with ...
Vincent M Janik, Götz Thomas, Gotz, Thomas, Janik Vincent M, Janik, Vincent, Thomas Götz   +5 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source