Results 41 to 50 of about 235,760 (301)

Contextual Fear Memory Maintenance Changes Expression of pMAPK, BDNF and IBA-1 in the Pre-limbic Cortex in a Layer-Specific Manner

Frontiers in Neural Circuits, 2021
Post-traumatic stress disorder (PTSD) is a debilitating and chronic fear-based disorder. Pavlovian fear conditioning protocols have long been utilised to manipulate and study these fear-based disorders.
Nicholas Chaaya, Nicholas Chaaya, Joshua Wang, Joshua Wang, Angela Jacques, Angela Jacques, Kate Beecher, Kate Beecher, Michael Chaaya, Michael Chaaya, Andrew Raymond Battle, Andrew Raymond Battle, Andrew Raymond Battle, Luke R. Johnson, Luke R. Johnson, Luke R. Johnson, Fatemeh Chehrehasa, Fatemeh Chehrehasa, Arnauld Belmer, Arnauld Belmer, Selena E. Bartlett, Selena E. Bartlett   +21 more
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Natural amyloid-β oligomers acutely impair the formation of a contextual fear memory in mice.

PLoS ONE, 2012
Memory loss is one of the hallmark symptoms of Alzheimer's disease (AD). It has been proposed that soluble amyloid-beta (Abeta) oligomers acutely impair neuronal function and thereby memory.
Kara A Kittelberger, Fabrizio Piazza, Giuseppina Tesco, Leon G Reijmers   +3 more
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mGluR5 in amygdala modulates fear memory generalization

Frontiers in Behavioral Neuroscience, 2023
IntroductionFear memory generalization is regarded as the core characteristic of posttraumatic stress disorder (PTSD) development. However, the mechanism that contributes to the generalization of conditioned fear memory is still unclear.
Shou-Min Xuan, Ya-Wen Su, Yi-Meng Liang, Zhen-Jie Gao, Chun-Yan Liu, Bu-Fang Fan, Yan-Wei Shi, Yan-Wei Shi, Xiao-Guang Wang, Xiao-Guang Wang, Hu Zhao, Hu Zhao   +11 more
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Correlations between psychological tests and physiological responses during fear conditioning and renewal [PDF]

, 2012
Background: Anxiety disorders are characterized by specific emotions, thoughts and physiological responses. Little is known, however, about the relationship between psychological/personality indices of anxiety responses to fear stimuli.
Castro-Couch, Melissa, Franco-Chaves, José A, Martínez, Karen G, Milad, Mohammed R, Ojeda-Arce, Brenda, Quirk, Gregory J, Segura, Gustavo   +6 more
core   +1 more source

Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala

Scientific Reports, 2017
Fear conditioning, a behavioral model for studying fear-related disorders, is believed to be formed by alterations of synaptic efficacy mediated by changes in synaptic transmission and neuronal morphology in lateral amygdala (LA).
Aniruddha Das, Monica Dines, Jessica M. Alapin, Raphael Lamprecht   +3 more
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Post-training Activation of Rac1 in the Basolateral Amygdala Is Required for the Formation of both Short-term and Long-term Auditory Fear Memory

Frontiers in Molecular Neuroscience, 2015
Rac1, a member of the Rho family of small GTPases, is crucial for morphological changes of the mature neuronal synapse including spine formation and activity-dependent spine enlargement, while its role in the formation of associated memories, such as ...
Qinqin eGao, Wenqing eYao, Junjun eWang, Tong eYang, Cao eLiu, Yezheng eTao, Yuejun eChen, Xing eLiu, Lan eMa   +8 more
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Sexually divergent expression of active and passive conditioned fear responses in rats

eLife, 2015
Traditional rodent models of Pavlovian fear conditioning assess the strength of learning by quantifying freezing responses. However, sole reliance on this measure includes the de facto assumption that any locomotor activity reflects an absence of fear ...
Tina M Gruene, Katelyn Flick, Alexis Stefano, Stephen D Shea, Rebecca M Shansky   +4 more
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Role of TRPC6 in conditioning and extinction of contextual fear memory in mice

Di-san junyi daxue xuebao, 2020
Objective To explore the role of transient receptor potential canonical 6 (TRPC6) on conditioning and extinction in contextual fear memory. Methods A total of 32 male C57BL/6J mice (6~8 weeks old) were randomized into fear conditioning (Cond group, n=16)
TIAN Yiqin, CHEN Xiuxiu, BIAN Chen, BIAN Chen, LI Min   +4 more
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Dopamine D1-like receptor signalling in the hippocampus and amygdala modulates the acquisition of contextual fear conditioning [PDF]

, 2015
RATIONALE: Dopamine D1-like receptor signalling is involved in contextual fear conditioning, but the brain regions involved and its role in other contextual fear memory processes remain unclear.
Bast, Tobias, Heath, Florence C., Jurkus, Regimantas, Lee, Jonathan L. C., Lee, Jonathan L.C., Pezze, Marie A., Stevenson, Carl W., Voigt, J. Peter, Voigt, Jörg-Peter   +8 more
core   +4 more sources

Fear Conditioning Assay in Mouse

Bio-Protocol, 2013
The study of fear memory is important for understanding various anxiety disorders in which patients experience persistent recollections of traumatic events.
Melissa Wang, Isabel Muzzio
doaj   +1 more source