Results 31 to 40 of about 716,992 (304)

Fear conditioning and the basolateral amygdala [PDF]

F1000Research, 2020
Fear is a response to impending threat that prepares a subject to make appropriate defensive responses, whether to freeze, fight, or flee to safety. The neural circuits that underpin how subjects learn about cues that signal threat, and make defensive responses, have been studied using Pavlovian fear conditioning in laboratory rodents as well as humans.
Yajie Sun, Helen Gooch, Pankaj Sah
openaire   +3 more sources

An organization of visual and auditory fear conditioning in the lateral amygdala [PDF]

, 2014
Pavlovian fear conditioning is an evolutionary conserved and extensively studied form of associative learning and memory. In mammals, the lateral amygdala (LA) is an essential locus for Pavlovian fear learning and memory.
Bergstrom, Hadley C., Johnson, Luke R.
core   +1 more source

Natural amyloid-β oligomers acutely impair the formation of a contextual fear memory in mice.

PLoS ONE, 2012
Memory loss is one of the hallmark symptoms of Alzheimer's disease (AD). It has been proposed that soluble amyloid-beta (Abeta) oligomers acutely impair neuronal function and thereby memory.
Kara A Kittelberger, Fabrizio Piazza, Giuseppina Tesco, Leon G Reijmers   +3 more
doaj   +1 more source

Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats [PDF]

, 2021
The RIβ subunit of cAMP-dependent protein kinase (PKA), encoded by Prkar1b, is a neuronal isoform of the type I regulatory subunit of PKA. Mice lacking the RIβ subunit exhibit normal long-term potentiation (LTP) in the Schaffer collateral pathway of the ...
Hieu, Hoang Trung, SHIRASUNA, Koumei, HIRATA, Yoshiki, KURAMOTO, Takashi, KUWAMURA, Mitsuru, NAKAO, Akito, YOSHIHARA, Toru, HAYASHIDA, Katsumi, ASANO, Masahide, NAKAGAWA, Yuki, MORI, Yasuo, KANEKO, Takehito   +11 more
core  

Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala

Scientific Reports, 2017
Fear conditioning, a behavioral model for studying fear-related disorders, is believed to be formed by alterations of synaptic efficacy mediated by changes in synaptic transmission and neuronal morphology in lateral amygdala (LA).
Aniruddha Das, Monica Dines, Jessica M. Alapin, Raphael Lamprecht   +3 more
doaj   +1 more source

Post-training Activation of Rac1 in the Basolateral Amygdala Is Required for the Formation of both Short-term and Long-term Auditory Fear Memory

Frontiers in Molecular Neuroscience, 2015
Rac1, a member of the Rho family of small GTPases, is crucial for morphological changes of the mature neuronal synapse including spine formation and activity-dependent spine enlargement, while its role in the formation of associated memories, such as ...
Qinqin eGao, Wenqing eYao, Junjun eWang, Tong eYang, Cao eLiu, Yezheng eTao, Yuejun eChen, Xing eLiu, Lan eMa   +8 more
doaj   +1 more source

Contextual Fear Memory Maintenance Changes Expression of pMAPK, BDNF and IBA-1 in the Pre-limbic Cortex in a Layer-Specific Manner

Frontiers in Neural Circuits, 2021
Post-traumatic stress disorder (PTSD) is a debilitating and chronic fear-based disorder. Pavlovian fear conditioning protocols have long been utilised to manipulate and study these fear-based disorders.
Nicholas Chaaya, Nicholas Chaaya, Joshua Wang, Joshua Wang, Angela Jacques, Angela Jacques, Kate Beecher, Kate Beecher, Michael Chaaya, Michael Chaaya, Andrew Raymond Battle, Andrew Raymond Battle, Andrew Raymond Battle, Luke R. Johnson, Luke R. Johnson, Luke R. Johnson, Fatemeh Chehrehasa, Fatemeh Chehrehasa, Arnauld Belmer, Arnauld Belmer, Selena E. Bartlett, Selena E. Bartlett   +21 more
doaj   +1 more source

Sexually divergent expression of active and passive conditioned fear responses in rats

eLife, 2015
Traditional rodent models of Pavlovian fear conditioning assess the strength of learning by quantifying freezing responses. However, sole reliance on this measure includes the de facto assumption that any locomotor activity reflects an absence of fear ...
Tina M Gruene, Katelyn Flick, Alexis Stefano, Stephen D Shea, Rebecca M Shansky   +4 more
doaj   +1 more source

mGluR5 in amygdala modulates fear memory generalization

Frontiers in Behavioral Neuroscience, 2023
IntroductionFear memory generalization is regarded as the core characteristic of posttraumatic stress disorder (PTSD) development. However, the mechanism that contributes to the generalization of conditioned fear memory is still unclear.
Shou-Min Xuan, Ya-Wen Su, Yi-Meng Liang, Zhen-Jie Gao, Chun-Yan Liu, Bu-Fang Fan, Yan-Wei Shi, Yan-Wei Shi, Xiao-Guang Wang, Xiao-Guang Wang, Hu Zhao, Hu Zhao   +11 more
doaj   +1 more source

Trace Fear Conditioning in Mice [PDF]

Journal of Visualized Experiments, 2014
In this experiment we present a technique to measure learning and memory. In the trace fear conditioning protocol presented here there are five pairings between a neutral stimulus and an unconditioned stimulus. There is a 20 sec trace period that separates each conditioning trial.
Joaquin N, Lugo, Gregory D, Smith, Andrew J, Holley   +2 more
openaire   +2 more sources