Maintenance of aversive memories shown by fear extinction-impaired phenotypes is associated with increased activity in the amygdaloid-prefrontal circuit [PDF]
, 2016 Although aversive memory has been mainly addressed by analysing the changes occurring in average populations, the study of neuronal mechanisms of outliers allows understanding the involvement of individual differences in fear conditioning and extinction.
Caioli, Silvia +5 more
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Extinction in Human Fear Conditioning [PDF]
Biological Psychiatry, 2006 Although most extinction research is conducted in animal laboratories, the study of extinction learning in human fear conditioning has gained increasing attention over the last decade. The most important findings from human fear extinction are reviewed in this article.
Hermans, Dirk +3 more
openaire +3 more sources
Functional imaging of stimulus convergence in amygdalar neurons during Pavlovian fear conditioning. [PDF]
PLoS ONE, 2009 BACKGROUND:Associative conditioning is a ubiquitous form of learning throughout the animal kingdom and fear conditioning is one of the most widely researched models for studying its neurobiological basis.
Sabiha K Barot +3 more
doaj +1 more source
Impaired contextual modulation of memories in PTSD: an fMRI and psychophysiological study of extinction retention and fear renewal [PDF]
, 2014 Post-traumatic stress disorder (PTSD) patients display pervasive fear memories, expressed indiscriminately. Proposed mechanisms include enhanced fear learning and impaired extinction or extinction recall. Documented extinction recall deficits and failure
Abelson, James L +6 more
core +1 more source
Modeling startle eyeblink electromyogram to assess fear learning [PDF]
, 2017 Pavlovian fear conditioning is widely used as a laboratory model of associative learning in human and nonhuman species. In this model, an organism is trained to predict an aversive unconditioned stimulus from initially neutral events (conditioned stimuli,
Bach, DR +4 more
core +2 more sources
Is conditioning a useful framework for understanding the development and treatment of phobias? [PDF]
, 2006 Despite the prevalence of therapeutic interventions based on conditioning models of fear acquisition, conditioning has been seen by many as a poor explanation of how fears develop: partly because research on conditioning has become less mainstream and ...
Aitken +87 more
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Frontiers in Behavioral Neuroscience, 2009 Early life trauma alters later life emotions, including fear. To better understand mediating mechanisms, we subjected pups to either predictable or unpredictable trauma, in the form of paired or unpaired odor-0.5mA shock conditioning which, during a ...
Stephanie Moriceau +11 more
doaj +1 more source
NR2A- and NR2B-containing NMDA Receptors in the Prelimbic Medial Prefrontal Cortex Differentially Mediate Trace, Delay, and Contextual Fear Conditioning [PDF]
, 2013 Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each association ...
Gilmartin, Marieke R. +2 more
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Putting fear in its place: remapping of hippocampal place cells during fear conditioning [PDF]
, 2004 We recorded hippocampal place cells in two spatial environments: a training environment in which rats underwent fear conditioning and a neutral control environment.
Blair, HT +4 more
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Hippocampal structural plasticity accompanies the resulting contextual fear memory following stress and fear conditioning [PDF]
, 2013 The present research investigated the resulting contextual fear memory and structural plasticity changes in the dorsal hippocampus (DH) following stress and fear conditioning. This combination enhanced fear retention and increased the number of total and
Calfa, Gaston Diego +2 more
core +1 more source