Results 31 to 40 of about 50,736 (309)

Natural amyloid-β oligomers acutely impair the formation of a contextual fear memory in mice.

PLoS ONE, 2012
Memory loss is one of the hallmark symptoms of Alzheimer's disease (AD). It has been proposed that soluble amyloid-beta (Abeta) oligomers acutely impair neuronal function and thereby memory.
Kara A Kittelberger, Fabrizio Piazza, Giuseppina Tesco, Leon G Reijmers   +3 more
doaj   +1 more source

Affecting long-term fear memory formation through optical control of Rac1 GTPase and PAK activity in lateral amygdala

Scientific Reports, 2017
Fear conditioning, a behavioral model for studying fear-related disorders, is believed to be formed by alterations of synaptic efficacy mediated by changes in synaptic transmission and neuronal morphology in lateral amygdala (LA).
Aniruddha Das, Monica Dines, Jessica M. Alapin, Raphael Lamprecht   +3 more
doaj   +1 more source

Post-training Activation of Rac1 in the Basolateral Amygdala Is Required for the Formation of both Short-term and Long-term Auditory Fear Memory

Frontiers in Molecular Neuroscience, 2015
Rac1, a member of the Rho family of small GTPases, is crucial for morphological changes of the mature neuronal synapse including spine formation and activity-dependent spine enlargement, while its role in the formation of associated memories, such as ...
Qinqin eGao, Wenqing eYao, Junjun eWang, Tong eYang, Cao eLiu, Yezheng eTao, Yuejun eChen, Xing eLiu, Lan eMa   +8 more
doaj   +1 more source

Contextual Fear Memory Maintenance Changes Expression of pMAPK, BDNF and IBA-1 in the Pre-limbic Cortex in a Layer-Specific Manner

Frontiers in Neural Circuits, 2021
Post-traumatic stress disorder (PTSD) is a debilitating and chronic fear-based disorder. Pavlovian fear conditioning protocols have long been utilised to manipulate and study these fear-based disorders.
Nicholas Chaaya, Nicholas Chaaya, Joshua Wang, Joshua Wang, Angela Jacques, Angela Jacques, Kate Beecher, Kate Beecher, Michael Chaaya, Michael Chaaya, Andrew Raymond Battle, Andrew Raymond Battle, Andrew Raymond Battle, Luke R. Johnson, Luke R. Johnson, Luke R. Johnson, Fatemeh Chehrehasa, Fatemeh Chehrehasa, Arnauld Belmer, Arnauld Belmer, Selena E. Bartlett, Selena E. Bartlett   +21 more
doaj   +1 more source

Fear memory modulation by incentive down and up-shifts

, 2022
Research on retrieval-induced malleability of maladaptive emotional memories has been mostly focused on the effect of drugs and extinction (i.e. post-retrieval extinction). Only a few studies addressed post-retrieval appetitive-aversive interactions. Due
Alfei, Joaquín M., Bueno, Adrián Marcelo, Ferrer Monti, Roque I., Urcelay, Gonzalo Pablo, Bueno, Adrian M., Mugnaini, Matías, Urcelay, Gonzalo P., Ferrer Monti, Roque Ignacio   +7 more
core   +1 more source

Sexually divergent expression of active and passive conditioned fear responses in rats

eLife, 2015
Traditional rodent models of Pavlovian fear conditioning assess the strength of learning by quantifying freezing responses. However, sole reliance on this measure includes the de facto assumption that any locomotor activity reflects an absence of fear ...
Tina M Gruene, Katelyn Flick, Alexis Stefano, Stephen D Shea, Rebecca M Shansky   +4 more
doaj   +1 more source

mGluR5 in amygdala modulates fear memory generalization

Frontiers in Behavioral Neuroscience, 2023
IntroductionFear memory generalization is regarded as the core characteristic of posttraumatic stress disorder (PTSD) development. However, the mechanism that contributes to the generalization of conditioned fear memory is still unclear.
Shou-Min Xuan, Ya-Wen Su, Yi-Meng Liang, Zhen-Jie Gao, Chun-Yan Liu, Bu-Fang Fan, Yan-Wei Shi, Yan-Wei Shi, Xiao-Guang Wang, Xiao-Guang Wang, Hu Zhao, Hu Zhao   +11 more
doaj   +1 more source

TIMING BEHAVIOR AND CONDITIONED FEAR [PDF]

Journal of the Experimental Analysis of Behavior, 1964
Rats were trained on a two‐response timing procedure which required that response B follow response A by at least a minimum specified interval in order to be reinforced with food. Repeated presentation (5 min on, 5 min off) of an auditory warning stimulus terminated by a brief electric shock to the feet (conditioned fear) produced a marked suppression ...
B, MIGLER, J V, BRADY
openaire   +2 more sources

The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans

, 2009
Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)- type glutamate receptors.
Dolan, RJ, Holt, Beatrice, Holt, B., Kalisch, R, Büchel, C, Martino, Benedetto de, Büchel, Christian, Dolan, R. ; https://orcid.org/, Kalisch, R., Büchel, C., Holt, B, Klöppel, Stefan, Dolan, R.J., Petrovic, P,, Petrovic, P., Petrovic, Predrag, De Martino, B., Klöppel, S., Dolan, Raymond J., De, Martino B, Kalisch, Raffael, Klöppel, S   +21 more
core   +1 more source

Role of TRPC6 in conditioning and extinction of contextual fear memory in mice

Di-san junyi daxue xuebao, 2020
Objective To explore the role of transient receptor potential canonical 6 (TRPC6) on conditioning and extinction in contextual fear memory. Methods A total of 32 male C57BL/6J mice (6~8 weeks old) were randomized into fear conditioning (Cond group, n=16)
TIAN Yiqin, CHEN Xiuxiu, BIAN Chen, BIAN Chen, LI Min   +4 more
doaj   +1 more source