Results 1 to 10 of about 19,755 (259)

Enhancing fear extinction [PDF]

eLife
Gradually reducing a source of fear during extinction treatments may weaken negative memories in the long term.
Sydney Trask, Nicole C Ferrara
doaj   +4 more sources

Dopamine in Fear Extinction [PDF]

Frontiers in Synaptic Neuroscience, 2021
The ability to extinguish fear memories when threats are no longer present is critical for adaptive behavior. Fear extinction represents a new learning process that eventually leads to the formation of extinction memories.
Ximena I. Salinas-Hernández, Sevil Duvarci   +1 more
doaj   +5 more sources

High ovarian hormones present during fear extinction reduce fear relapse through a nigrostriatal dopamine pathway [PDF]

Biology of Sex Differences
Background Elevated ovarian hormones during fear extinction can enhance fear extinction memory retention and reduce fear renewal, but the mechanisms remain unknown. High levels of ovarian hormones are associated with heightened dopamine (DA) transmission,
Alyssa A. Hohorst, Margaret K. Tanner, Rebecca Han, Kamryn M. Korth, Jessica D. Westerman, Carolina Sanchez Mendoza, Miles Q. Dryden, Lareina A. Alvarez, Remla A. Abdul, Esteban C. Loetz, Erik B. Oleson, Benjamin N. Greenwood   +11 more
doaj   +2 more sources

Fear extinction retention in children, adolescents, and adults [PDF]

Developmental Cognitive Neuroscience
Past results suggest that fear extinction and the return of extinguished fear are compromised in adolescents. However, findings have been inconclusive as there is a lack of fear extinction and extinction retention studies including children, adolescents ...
Ebba Widegren, Johan Vegelius, Matilda A. Frick, Ashika A. Roy, Stefan Möller, Johan Lundin Kleberg, Johanna Motilla Hoppe, Olof Hjorth, David Fällmar, Daniel S. Pine, Karin Brocki, Malin Gingnell, Andreas Frick   +12 more
doaj   +2 more sources

Transcriptomic Architecture of Weak Versus Strong Contextual Fear Extinction Learning Uncovers Extinction-Suppressive Role of TIA1 [PDF]

Biological Psychiatry Global Open Science
Background: Extinction, the capacity for an individual to inhibit or diminish fear memories, is a critical aspect of fear processing. In humans, weak extinction learning is often observed in anxiety and fear-related disorders such as posttraumatic stress
Maria I. Bonilla, Hae-Lim Lee, Stephen Foster, In-Jung Kim, Andrii Rudenko   +4 more
doaj   +2 more sources

Chemogenetic modulation of CRF neurons in the BNST compensates for phenotypic behavioral differences in fear extinction learning of 5-HT2C receptor mutant mice [PDF]

Translational Psychiatry
Psychopharmacotherapy is often used to treat anxiety- and stress-associated psychiatric disorders, including post-traumatic stress disorder (PTSD). Adjunctive therapy is most typically used with medications that influence serotonin balance, such as ...
Hannah Schulte, Hanna Böke, Patricia Lössl, Maria Worm, Ida Siveke, Stefan Herlitze, Katharina Spoida   +6 more
doaj   +2 more sources

A neurally constrained computational model of context-dependent fear extinction recall and relapse [PDF]

Communications Biology
Exposure therapy, a standard treatment for anxiety disorders, relies on fear extinction. However, extinction recall is often limited to the spatial and temporal context in which extinction is learned, leading to fear relapse in new settings or after ...
Shreya K. Rajagopal, Thad A. Polk
doaj   +2 more sources

Deleting “fear” from “fear extinction”: Estimating the individual extinction rate via non-aversive conditioning [PDF]

Behaviour Research and Therapy, 2021
Individual differences in extinction learning have attracted ample attention of researchers and are under investigation as a marker for the onset of anxiety disorders and treatment response. Unfortunately, the common paradigm for obtaining the extinction rate, which entails aversive stimulus pairings, is subject to practical limitations. Therefore, the
Michelle Spix, Miriam J.J. Lommen, Yannick Boddez   +2 more
openaire   +4 more sources

Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats

Frontiers in Pharmacology, 2022
Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can enhance extinction,
William G. Warren, Eleni P. Papagianni, Ed Hale, Rebecca A. Brociek, Helen J. Cassaday, Carl W. Stevenson   +5 more
doaj   +1 more source

Mechanisms of fear extinction [PDF]

Molecular Psychiatry, 2006
Excessive fear and anxiety are hallmarks of a variety of disabling anxiety disorders that affect millions of people throughout the world. Hence, a greater understanding of the brain mechanisms involved in the inhibition of fear and anxiety is attracting increasing interest in the research community.
K M, Myers, M, Davis
openaire   +2 more sources