Results 71 to 80 of about 637,566 (254)

Silk Fibroin Nanofiber–Immobilized Horseradish Peroxidase Enables Continuous Preparation of Injectable Hydrogels With Negligible Residual Enzyme for Drug Delivery

Advanced Materials Technologies, EarlyView.
Overcoming the immunogenicity challenges of enzyme‐mediated crosslinking, a flow‐through reactor utilizing SFNF‐HRP enables the continuous production of injectable hydrogels. This continuous platform ensures homogeneous crosslinking while minimizing residual HRP in the resulting hydrogels.
Ayari Miyawaki, Shinji Sakai
wiley   +1 more source

The effects of spaced versus massed extinction training on extinction retention of conditioned fear learning in male rats

Frontiers in Behavioral Neuroscience
IntroductionExtinction learning of conditioned fear behavior has been used as a translational model to study human fear-, anxiety-, trauma-, and stressor-related disorders and their underlying neurobiology in animal models because the underlying neural ...
Grant W. LeVasseur, Timothy Cilley, Michelle Szewczuk, Shane A. Perrine, Seth D. Norrholm   +4 more
doaj   +1 more source

Plasticity of fear and safety neurons of the amygdala in response to fear extinction

Frontiers in Behavioral Neuroscience, 2015
Fear inhibition learning induces plasticity and remodeling of circuits within the amygdala. Most studies examine these changes in nondiscriminative fear conditioning paradigms.
Susan eSangha, Susan eSangha
doaj   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Interação entre os sistemas endocanabinóide e glicocorticóide na extinção do condicionamento aversivo contextual em ratos [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA regulação das respostas emocionais é essencial para a saúde mental e a forma mais simples de regulação destas respostas é
Bitencourt, Rafael Mariano de
core  

Predicting Fear Extinction in Posttraumatic Stress Disorder

, 2023
Fear extinction is the basis of exposure therapies for posttraumatic stress disorder (PTSD), but half of patients do not improve. Predicting fear extinction in individuals with PTSD may inform personalized exposure therapy development.
Christian A. Webb, Sydney A. Jobson, Michael W. Lewis, Manuel Kuhn, Eylül Akman, Isabelle M. Rosso   +5 more
core   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Attentional Control and Fear Extinction in Subclinical Fear: An Exploratory Study

Frontiers in Psychology, 2017
Attentional control (AC) and fear extinction learning are known to be involved in pathological anxiety. In this study we explored whether individual differences in non-emotional AC were associated with individual differences in the magnitude and gradient
Eduard Forcadell, Eduard Forcadell, David Torrents-Rodas, David Torrents-Rodas, Devi Treen, Miquel A. Fullana, Miquel A. Fullana, Miquel A. Fullana, Miquel Tortella-Feliu, Miquel Tortella-Feliu   +9 more
doaj   +1 more source

The role of NMDA receptors in the extinction and re-extinction of Pavlovian fear conditioning [PDF]

, 2010
The present thesis examined the role of N-methyl-D-apsartate receptors (NMDArs) in the extinction and re-extinction of Pavlovian fear conditioning in the rat.
Langton, Julia Michele
core   +1 more source