Results 231 to 240 of about 7,060,917 (288)

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Advanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García, Kerry R. McGreevy, Maria Eugenia Vaquero, Juan M. Suarez‐Rivero, Antonio Moreno‐Rodríguez, Antonio J. Pérez‐Pulido, Daniel Ramírez de Mingo, Anna Pallé, Helena Akiko Popiel, Andrea Santi, Mario D. Cordero, José Luis Trejo, Yoshitaka Nagai, Mariano Carrión‐Vázquez   +13 more
wiley   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

CS - plasticity and behavioral-state integration in the posterior insula during auditory fear learning

Osypenko D, Palchaudhuri S, Kochubey O, Schneggenburger R.   +3 more
europepmc   +1 more source

Dorsal hippocampal astrocytes mediate the development of heroin withdrawal-enhanced fear learning. [PDF]

Psychopharmacology (Berl)
Parekh SV, Adams LO, Barkell GA, Paniccia JE, Reissner KJ, Lysle DT.   +5 more
europepmc   +1 more source

5-HT_2C Receptors in the BNST Modulate Contextual Fear Conditioning Without Affecting Acute Early Life Stress-Enhanced Fear Learning in Adult Rats. [PDF]

Brain Sci
Minshall BL, Wasylyshyn CF, Brand KM, Bartoszek CM, Seipel KA, Booms MM, Chappell LC, Reichert AN, Dowell JR, Buck AL, Beckett HT, Lowry CA, Quinn JJ.   +12 more
europepmc   +1 more source

Contingency Reversal in Conditioned Fear Learning: The Moderated Mediation Model of Intolerance of Uncertainty and Instruction. [PDF]

Psychol Res Behav Manag
Gao Y, Fan M, Li Y, Zhao S, Chen W, Zhang D, Zheng X.   +6 more
europepmc   +1 more source

Mild Deficits in Fear Learning: Evidence from Humans and Mice with Cerebellar Cortical Degeneration. [PDF]

eNeuro
Batsikadze G, Pakusch J, Klein M, Ernst TM, Thieme A, Nicksirat SA, Steiner KM, Nio E, Genc E, Maderwald S, Deuschl C, Merz CJ, Quick HH, Mark MD, Timmann D.   +14 more
europepmc   +1 more source

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The neuropsychology of fear learning and fear regulation

International Journal of Psychophysiology, 2005
In the current review article it is suggested that fear is a central emotional state that can be activated by external threat cues. The subcortical defensive system cannot only be activated by intrinsically aversive events but shows also strong plasticity enabling previously innocuous stimuli to get access to the fear system after they were paired with
Alfons O, Hamm, Almut I, Weike
openaire   +2 more sources

The learning of fear extinction

Neuroscience & Biobehavioral Reviews, 2014
Recent work on the extinction of fear-motivated learning places emphasis on its putative circuitry and on its modulation. Extinction is the learned inhibition of retrieval of previously acquired responses. Fear extinction is used as a major component of exposure therapy in the treatment of fear memories such as those of the posttraumatic stress ...
Cristiane, Furini, Jociane, Myskiw, Ivan, Izquierdo   +2 more
openaire   +2 more sources