Results 11 to 20 of about 483,021 (202)

Versatility of Fear-potentiated Startle Paradigms for Assessing Human Conditioned Fear Extinction and Return of Fear [PDF]

Frontiers in Behavioral Neuroscience, 2011
Fear conditioning methodologies have often been employed as testable models for assessing learned fear responses in individuals with anxiety disorders such as post-traumatic stress disorder (PTSD) and specific phobia.
Seth Davin Norrholm, Kemp M Anderson, Ilana W Olin, Tanja eJovanovic, Cliffe eKwon, Victor T Warren, Alexander eMcCarthy, Lauren eBosshardt, Justin eSabree, Justin eSabree, Erica J Duncan, Barbara O Rothbaum, Bekh eBradley   +12 more
doaj   +5 more sources

Distinct Contributions of Median Raphe Nucleus to Contextual Fear Conditioning and Fear-Potentiated Startle

Neural Plasticity, 2002
Ascending 5-HT projections from the median raphe nucleus (MRN), probably to the hippocampus, are implicated in the acquisition of contextual fear (background stimuli), as assessed by freezing behavior.
R. C. B. Silva, A. P. M. Cruz, V. Avanzi, J. Landeira-Fernandez, M. L. Brandão   +4 more
doaj   +2 more sources

Pharmacology of the Fear potentiated startle test in animals

, 2023
Systematic review and meta-analysis of drug effects in the fear-potentiated startle test in animals. The review was limited to studies using acute, systemic drug administration in naive animals. Project aims: 1. determine which drug classes alter the expression of conditioned fear in the fear potentiated startle test. 2.
Groenink, Lucianne, Verdouw, Pia Monika
openaire   +2 more sources

Contextual fear conditioning in virtual reality is affected by 5HTTLPR and NPSR1 polymorphisms: effects on fear-potentiated startle [PDF]

Frontiers in Behavioral Neuroscience, 2013
The serotonin (5-HT) and neuropeptide S (NPS) systems are discussed as important genetic modulators of fear and sustained anxiety contributing to the etiology of anxiety disorders.
Evelyn eGlotzbach-Schoon, Marta eAndreatta, Andreas eReif, Heike eEwald, Christian eTröger, Christian eBaumann, Christian eBaumann, Jürgen eDeckert, Andreas eMühlberger, Andreas eMühlberger, Paul ePauli   +10 more
doaj   +2 more sources

Fear, Startle, and Fear-Potentiated Startle : Probing Emotion in the Human Brain

, 2003
The present thesis explored the neurobiological basis of three aspects of defense behaviors in humans. Positron emission tomography methodology was used, and changes in regional cerebral blood flow (rCBF) were measured as an index of neural activity. Firstly, brain function was studied in a group of patients suffering from combat-related posttraumatic ...
Pissiota, Anna
core   +4 more sources

Immediate pre-learning stress enhances baseline startle response and fear acquisition in a fear-potentiated startle paradigm. [PDF]

Behav Brain Res, 2019
Extensive work has shown that stress time-dependently influences hippocampus-dependent learning and memory. In particular, stress that is administered immediately before learning enhances long-term memory, while stress that is temporally separated from learning impairs long-term memory.
Riggenbach MR, Weiser JN, Mosley BE, Hipskind JJ, Wireman LE, Hess KL, Duffy TJ, Handel JK, Kaschalk MG, Reneau KE, Rorabaugh BR, Norrholm SD, Jovanovic T, Zoladz PR.   +13 more
europepmc   +4 more sources

Childhood Maltreatment in Females Is Associated with Enhanced Fear Acquisition and an Overgeneralization of Fear

Brain Sciences, 2022
Childhood maltreatment may alter fear neurocircuitry, which results in pathological anxiety and depression. One alteration of fear-related behaviors that has been observed in several psychiatric populations is an overgeneralization of fear.
Phillip Zoladz, Kassidy Reneau, Jordan Weiser, Chloe Cordes, Emma Virden, Sara Helwig, Caitlin Thebeault, Cassidy Pfister, Bruktawit Getnet, Kayla Boaz, Taylor Niese, Mercedes Stanek, Kristen Long, Sydney Parker, Boyd Rorabaugh, Seth Norrholm   +15 more
doaj   +1 more source

Behavioral Expression of Contextual Fear in Male and Female Rats

Frontiers in Behavioral Neuroscience, 2021
The study of fear conditioning has led to a better understanding of fear and anxiety-based disorders such as post-traumatic stress disorder (PTSD). Despite the fact many of these disorders are more common in women than in men, the vast majority of work ...
Amanda S. Russo, Ryan G. Parsons
doaj   +1 more source

Heart Rate Variability Features as Predictors of Intermittent Theta‐Burst Stimulation Response in Posttraumatic Stress Disorder

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Background Posttraumatic stress disorder (PTSD) is associated with autonomic dysfunction as indicated by deficits in the sympathetic and parasympathetic nervous systems. These abnormalities are expressed as elevated heart rate and reduced heart rate variability (HRV), respectively.
Camila Cosmo, Antonia V. Seligowski, Emily M. Aiken, Mascha van't Wout‐Frank, Noah S. Philip   +4 more
wiley   +1 more source

Developmental investigation of fear-potentiated startle across puberty. [PDF]

Biol Psychol, 2014
The goal of this study was to examine the association between affective development, puberty, and gender using the startle reflex as a marker of defensive mechanisms. Thirty-one male and thirty-five female adolescents aged ten to thirteen participated in a prospective study with up to five assessments.
Schmitz A, Grillon C, Avenevoli S, Cui L, Merikangas KR.   +4 more
europepmc   +4 more sources