Results 61 to 70 of about 946,604 (274)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Picking groups instead of samples: a close look at Static Pool-based Meta-Active Learning [PDF]

, 2019
©2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new ...
Mas Méndez, Ignasi, Morros Rubió, Josep Ramon, Vilaplana Besler, Verónica   +2 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Three-Dimensional Weld Pool Monitoring and Penetration State Recognition for Variable-Gap Keyhole Tungsten Inert Gas Welding Based on Stereo Vision

Sensors
K-TIG welding offers the advantages of single-sided welding and double-sided formation, making it widely used for medium/thick-plate welding. The welding quality of K-TIG is closely linked to its penetration state.
Zishun Wang, Yonghua Shi, Yanxin Cui, Wenqian Yan   +3 more
doaj   +1 more source

Contrastive Self-Supervised Two-Domain Residual Attention Network with Random Augmentation Pool for Hyperspectral Change Detection

Remote Sensing, 2023
Hyperspectral images can assist change-detection methods in precisely identifying differences in land cover in the same region at different observation times.
Yixiang Huang, Lifu Zhang, Wenchao Qi, Changping Huang, Ruoxi Song   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Comprehensive Fault Diagnosis Method for Rolling Bearings Based on Refined Composite Multiscale Dispersion Entropy and Fast Ensemble Empirical Mode Decomposition

Entropy, 2019
This study presents a comprehensive fault diagnosis method for rolling bearings. The method includes two parts: the fault detection and the fault classification.
Weibo Zhang, Jianzhong Zhou
doaj   +1 more source

Differentiable Pooling for Hierarchical Feature Learning

, 2012
We introduce a parametric form of pooling, based on a Gaussian, which can be optimized alongside the features in a single global objective function. By contrast, existing pooling schemes are based on heuristics (e.g. local maximum) and have no clear link to the cost function of the model.
Zeiler, Matthew D., Fergus, Rob
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Melt Pool Width Extraction Method in Laser Directed Energy Deposition Based on Variable Step Size Erosion Model

IEEE Access
To solve the problem of insufficient melt pool width feature extraction accuracy caused by splash, arc light, and other interferences in the metal deposition process, a melt pool width extraction method based on the variable step size erosion model is ...
Yuanxin Chai, Liguo Miao, Jinghu Tang, Dianqi Li   +3 more
doaj   +1 more source