Results 101 to 110 of about 3,973,078 (288)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Feature Interactions Outside a Telecom Domain [PDF]

open access: yes, 2001
Feature interactions in the original sense of the term (i.e. within a telecommunications domain), have now been the subject of significant research activity for over ten years.
Lynne Blair (7588349)   +7 more
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Oregon T2 Center's Oregon roads newsletter summer 1998-

open access: yes, 2003
Information about serial cessation provided by Oregon Department of Transportation on May 25, 2022."A quarterly publication for local governments responsible for roads, bridges, and public transportation."Title from captionMode of access: Internet from ...

core  

Heat transfer during film condensation of potassium vapor [PDF]

open access: yes, 1966
The object of this work is to investigate theoretically and experimentally the following two phases of heat transfer during condensation of potassium vapore, a.
Kroger, Detlev Gustav
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Heat transfer to impacting drops and post critical heat flux dispersed flow

open access: yes, 1978
Heat transfer to drops impacting on a hot surface is examined in context of dispersions of flowing, boiling fluids. The liquid contribution to heat transfer from a hot tube to a two-phase dispersion is formulated in terms of heat transfer contributions ...
Kendall, Gail E., Rohsenow, Warren M.
core  

Feature-Based Federated Transfer Learning: Communication Efficiency, Robustness and Privacy

open access: yesIEEE Transactions on Machine Learning in Communications and Networking
In this paper, we propose feature-based federated transfer learning as a novel approach to improve communication efficiency by reducing the uplink payload by multiple orders of magnitude compared to that of existing approaches in federated learning and ...
Feng Wang   +2 more
doaj   +1 more source

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