Results 51 to 60 of about 5,633 (190)

Febuxostat ameliorates methotrexate-induced lung damage

, 2021
Background: The intention of the present study was to assess the structural affection of the lung following methotrexate (MTX) overdose. The proposed underlying mechanisms involved in lung affection were studied.
Khalil, H. M.A.; Department of Veterinary Hygiene and Management, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt, Hussein, G. H.A.; Department of Anatomy and Embryology, Faculty of Medicine, Beni Suef University, Beni-Suef, Egypt, Abd Algaleel, W. A.; Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, Egypt, Zaki, S. M.; Fakeeh College for Medical Sciences, Jeddah, Saudi Arabia; Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, Egypt   +3 more
core   +1 more source

Impact of febuxostat on visit-to-visit blood pressure variability: insights from the randomised PRIZE Study

RMD Open, 2022
Objectives Although uric acid lowering therapies, including xanthine oxidase (XO) inhibition, may reduce the absolute level of blood pressure (BP), the effect of XO inhibition on BP variability is largely unknown.
Yoshio Kobayashi, Atsushi Tanaka, Yuichi Saito, Daigaku Uchida, Koichi Node, Naoto Yokota, Hisako Yoshida, Yuji Koide, Kazuo Matsunaga, Chikara Ueyama   +9 more
doaj   +1 more source

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, EarlyView.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

Sono‐Vasomics With Super‐Resolution Contrast‐Enhanced Ultrasound (SR‐CEUS) for Characterization of Focal Liver Lesions: A Case Report

Portal Hypertension &Cirrhosis, EarlyView.
ABSTRACT Accurate differentiation between benign and malignant focal liver lesions (FLLs) remains a major diagnostic challenge. Vasomics, an emerging discipline, classifies vascular phenotypes into anatomical, biomechanical, biochemical, pathophysiological, and composite categories. Sono‐Vasomics, the ultrasound‐based subset, leverages super‐resolution
Yijie Qiu, Ying Wang, Rui Cheng, Ruiling He, Yi Dong, Christoph F. Dietrich   +5 more
wiley   +1 more source

Chemical structures of febuxostat, ursolic acid and other xanthine oxidase inhibitors; allopurinol and febuxostat.

, 2018
Chemical structures of febuxostat, ursolic acid and other xanthine oxidase inhibitors; allopurinol and febuxostat.
Eman Abu-Gharbieh (3933140), Yasser Bustanji (2412991), Ihab M. Almasri (5638808), Naglaa G. Shehab (5638805)   +3 more
core   +1 more source

Cardiovascular Safety of Febuxostat and Allopurinol in Hyperuricemic Patients With or Without Gout: A Network Meta-Analysis

Frontiers in Medicine, 2021
Background: Hyperuricemia is a common metabolic disease and has become a public health problem because of its increasing prevalence and association with comorbidities.
Shengzhao Zhang, Shengzhao Zhang, Ting Xu, Ting Xu, Qingyang Shi, Sheyu Li, Sheyu Li, Ling Wang, Zhenmei An, Na Su, Na Su   +10 more
doaj   +1 more source

Nebenwirkungen und Interaktionen des Xanthinoxidasehemmers Febuxostat [PDF]

, 2017
Anzeichen für einen positiven Einfluss von Febuxostat auf die Aktivität der Xanthinoxidase in den Gefäßwänden und die Gefäßelastizität lassen eine Zunahme der Bedeutung dieses Medikaments erwarten.
Jordan, Andreas
core  

Febuxostat and other drugs labeled for cardiovascular risk regulate similar signaling pathways.

, 2023
A) Structures of febuxostat, oxypurinol, topiroxostat, and febuxostat-1. B) The total number of pathways regulated by drugs with known cardiovascular risk that are also regulated by febuxostat (FBX), febuxostat-1 (FBX-1), topiroxostat (TPS), oxypurinol ...
Justin Taylor (338383), Brian D. LaMoreaux (16955386), Ryan E. Feaver (16955371), Banumathi K. Cole (16955377), Brian A. Johns (1833643), Andrew C. Nyborg (3597386), Robert A. Figler (10639022), Steve Hoang (16955380), Brad R. Henke (1453429), Lin Zhao (92451), M. Scott Bowers (16955374), Brian R. Wamhoff (199470), Mark J. Lawson (16955383)   +12 more
core   +1 more source

The efficacy and safety of febuxostat for urate lowering in gout patients ≥65 years of age

BMC Geriatrics, 2012
Background The incidence of gout rises with increasing age. Management of elderly (≥65 years) gout patients can be challenging due to high rates of comorbidities, such as renal impairment and cardiovascular disease, and concomitant medication use ...
Jackson Robert L, Hunt Barbara, MacDonald Patricia A   +2 more
doaj   +1 more source